Filgen Fung1, Sylvie D Cornacchi1, Michael Reedijk2, Nicole Hodgson3, Charlie H Goldsmith4, David McCready2, Gabriela Gohla5, Colm Boylan6, Peter J Lovrics7. 1. Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada. 2. Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada. 3. Department of Surgical Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada. 4. Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Arthritis Research Canada, Richmond, BC, Canada. 5. Department of Pathology, McMaster University, Hamilton, ON, Canada. 6. Department of Radiology, McMaster University, Hamilton, ON, Canada. 7. Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada. Electronic address: lovricsp@mcmaster.ca.
Abstract
BACKGROUND: This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery. METHODS: Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)). Univariate analysis was used. RESULTS: Follow-up data were available for 298 patients (98%) and median follow-up time was 65 months. There were 11 (4%) cases of BC recurrence and median time to recurrence was 26 months. LR occurred in 8 patients (6 WL and 2 RSL; p = 0.28). Positive margins at first surgery (p = 0.024) and final surgery (p = 0.004) predicted for BC recurrence. CONCLUSIONS: There was no detectable difference in BC recurrence between WL and RSL groups and positive margins at initial or final surgery both predicted for BC recurrence.
RCT Entities:
BACKGROUND: This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery. METHODS: Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)). Univariate analysis was used. RESULTS: Follow-up data were available for 298 patients (98%) and median follow-up time was 65 months. There were 11 (4%) cases of BC recurrence and median time to recurrence was 26 months. LR occurred in 8 patients (6 WL and 2 RSL; p = 0.28). Positive margins at first surgery (p = 0.024) and final surgery (p = 0.004) predicted for BC recurrence. CONCLUSIONS: There was no detectable difference in BC recurrence between WL and RSL groups and positive margins at initial or final surgery both predicted for BC recurrence.
Authors: David H Kim; Theresa K Webster; Joseph G Bartolacci; Sthefano Araya; Juliet Panichella; Sameer A Patel Journal: Plast Reconstr Surg Glob Open Date: 2022-04-25