Literature DB >> 27809705

Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.

Karina Valdés1, Javier Morales1, Lennin Rodríguez2, Germán Günther3.   

Abstract

Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders treatment development. Nanotechnology can enhance solubility, stability, bioavailability and phytochemical delivery, improving the therapeutic efficiency of triterpenes. This review focuses on the formulation, characterization and in vitro/in vivo evaluation of several delivery nanosystems used to enhance the physicochemical properties of ursolic, oleanolic and betulinic acids.

Entities:  

Keywords:  antitumoral; betulinic acid; liposomes; nanocarriers; nanoemulsion; nanoparticles; nanosystems; nanotechnology; oleanolic acid; ursolic acid

Mesh：

Substances：

Year:  2016        PMID： 27809705     DOI： 10.2217/nnm-2016-0251

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  8 in total

1.  Amelioration effects of nanoencapsulated triterpenoids from petri dish-cultured Antrodia cinnamomea on reproductive function of diabetic male rats.

Authors:  Sabri Sudirman; Yuan-Hua Hsu; Athira Johnson; David Tsou; Zwe-Ling Kong
Journal:  Int J Nanomedicine       Date:  2018-09-04

Review 2.  The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer.

Authors:  Beatriz Martínez-Poveda; José Antonio Torres-Vargas; María Del Carmen Ocaña; Melissa García-Caballero; Miguel Ángel Medina; Ana R Quesada
Journal:  Nutrients       Date:  2019-08-31       Impact factor: 5.717

Review 3.  Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents.

Authors:  Codruţa Şoica; Mirela Voicu; Roxana Ghiulai; Cristina Dehelean; Roxana Racoviceanu; Cristina Trandafirescu; Oana-Janina Roșca; Gabriela Nistor; Marius Mioc; Alexandra Mioc
Journal:  Front Endocrinol (Lausanne)       Date:  2021-01-21       Impact factor: 5.555

Review 4.  The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges.

Authors:  Andreea Milan; Alexandra Mioc; Alexandra Prodea; Marius Mioc; Roxana Buzatu; Roxana Ghiulai; Roxana Racoviceanu; Florina Caruntu; Codruţa Şoica
Journal:  Int J Mol Sci       Date:  2022-01-20       Impact factor: 5.923

Review 5.  State-of-the-Art and Opportunities for Bioactive Pentacyclic Triterpenes from Native Mexican Plants.

Authors:  Juan Antonio Alfaro-Almaguer; Luis Alberto Mejía-Manzano; José González-Valdez
Journal:  Plants (Basel)       Date:  2022-08-23

6.  Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone.

Authors:  Monika Kadela-Tomanek; Maria Jastrzębska; Krzysztof Marciniec; Elwira Chrobak; Ewa Bębenek; Stanisław Boryczka
Journal:  Pharmaceutics       Date:  2021-05-23       Impact factor: 6.321

7.  Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced Damage Are Mediated through the Modulation of Diverse Inflammatory Mediators.

Authors:  Hong Wang; Meng-Kwoon Sim; Weng Keong Loke; Arunachalam Chinnathambi; Sulaiman Ali Alharbi; Feng Ru Tang; Gautam Sethi
Journal:  Front Pharmacol       Date:  2017-06-16       Impact factor: 5.810

Review 8.  Evolution from small molecule to nano-drug delivery systems: An emerging approach for cancer therapy of ursolic acid.

Authors:  Jingwei Shao; Yifan Fang; Ruirui Zhao; Fangmin Chen; Mingyue Yang; Jiali Jiang; Zixuan Chen; Xiaotian Yuan; Lee Jia
Journal:  Asian J Pharm Sci       Date:  2020-03-21       Impact factor: 6.598
  8 in total

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