Xiao-Ling Ren1,2, Wei Fu2, Jing Liu1,2, Ying Liu1, Rong-Ming Xia1. 1. a Department of Neonatology and NICU , Beijing Chaoyang District Maternal and Child Health Care Hospital , Beijing , China and. 2. b Department of Neonatology and NICU of Bayi Children's Hospital , the Army General Hospital of the Chinese PLA , Beijing , China.
Abstract
OBJECTIVES: This study was aimed to investigate the application of lung ultrasound for the diagnosis of pulmonary hemorrhage of the newborn (PHN). METHODS: From July 2013 to June 2016, 157 neonates were enrolled in the study. They were divided into two groups: a study group of 57 neonates, who were diagnosed with PHN according to their medical history, clinical manifestations and chest X-ray findings, and a control group of 100 neonates with no lung disease. All subjects underwent bedside lung ultrasound in a quiet state in a supine, lateral or prone position, performed by a single expert physician. The ultrasound findings were compared between the two groups. RESULTS: The lung ultrasound main findings associated with PHN included lung consolidation with air bronchograms with an incidence of 82.5%, a shred sign with an incidence of 91.2%, pleural effusion with an incidence of 84.2% (pleurocentesis confirmed the fluid was really bleeding), atelectasis with a incidence of 33.3%, pleural line abnormalities, as well as disappearing A-lines with an incidence of 100%, and 11.9% of these patients had the main manifestations of alveolar-interstitial syndrome (AIS). The shred sign exhibited a sensitivity of 91.2% and a specificity of 100% in diagnosing PHN. CONCLUSIONS: Lung ultrasonography is useful and reliable for diagnosing PHN, which is suitable for routine application in the neonatal intensive care unit.
OBJECTIVES: This study was aimed to investigate the application of lung ultrasound for the diagnosis of pulmonary hemorrhage of the newborn (PHN). METHODS: From July 2013 to June 2016, 157 neonates were enrolled in the study. They were divided into two groups: a study group of 57 neonates, who were diagnosed with PHN according to their medical history, clinical manifestations and chest X-ray findings, and a control group of 100 neonates with no lung disease. All subjects underwent bedside lung ultrasound in a quiet state in a supine, lateral or prone position, performed by a single expert physician. The ultrasound findings were compared between the two groups. RESULTS: The lung ultrasound main findings associated with PHN included lung consolidation with air bronchograms with an incidence of 82.5%, a shred sign with an incidence of 91.2%, pleural effusion with an incidence of 84.2% (pleurocentesis confirmed the fluid was really bleeding), atelectasis with a incidence of 33.3%, pleural line abnormalities, as well as disappearing A-lines with an incidence of 100%, and 11.9% of these patients had the main manifestations of alveolar-interstitial syndrome (AIS). The shred sign exhibited a sensitivity of 91.2% and a specificity of 100% in diagnosing PHN. CONCLUSIONS: Lung ultrasonography is useful and reliable for diagnosing PHN, which is suitable for routine application in the neonatal intensive care unit.