Gaiane M Rauch1, Beatriz Elena Adrada2, Henry Mark Kuerer3, Raquel F D van la Parra3, Jessica W T Leung2, Wei Tse Yang4. 1. 1 Department of Diagnostic Radiology, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009. 2. 2 Department of Diagnostic Radiology, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, TX. 3. 3 Department of Breast Surgical Oncology, Unit 1434, The University of Texas MD Anderson Cancer Center, Houston, TX. 4. 4 Department of Diagnostic Radiology, Unit 1459, The University of Texas MD Anderson Cancer Center, Houston, TX.
Abstract
OBJECTIVE: Neoadjuvant chemotherapy is becoming the standard of care for patients with locally advanced breast cancer. Conventional imaging modalities used for the assessment of tumor response to neoadjuvant chemotherapy rely on changes in size or morphologic characteristics and, therefore, are inherently limited. CONCLUSION: Functional imaging technologies evaluate vascular, metabolic, biochemical, and molecular changes in cancer cells and have a unique ability to detect specific biologic tumor markers, assess therapeutic targets, predict early response to neoadjuvant chemotherapy, and guide individualized cancer therapy.
OBJECTIVE: Neoadjuvant chemotherapy is becoming the standard of care for patients with locally advanced breast cancer. Conventional imaging modalities used for the assessment of tumor response to neoadjuvant chemotherapy rely on changes in size or morphologic characteristics and, therefore, are inherently limited. CONCLUSION: Functional imaging technologies evaluate vascular, metabolic, biochemical, and molecular changes in cancer cells and have a unique ability to detect specific biologic tumor markers, assess therapeutic targets, predict early response to neoadjuvant chemotherapy, and guide individualized cancer therapy.
Entities:
Keywords:
breast MRI; breast PET; breast cancer; molecular breast imaging; neoadjuvant chemotherapy
Authors: J K Litton; M Scoggins; D L Ramirez; R K Murthy; G J Whitman; K R Hess; B E Adrada; S L Moulder; C H Barcenas; V Valero; J Schwartz Gomez; E A Mittendorf; A Thompson; T Helgason; G B Mills; H Piwnica-Worms; B K Arun Journal: NPJ Breast Cancer Date: 2017-12-06
Authors: Nara P Pereira; Carla Curi; Cynthia A B T Osório; Elvira F Marques; Fabiana B Makdissi; Katja Pinker; Almir G V Bitencourt Journal: Sci Rep Date: 2019-11-08 Impact factor: 4.379