Literature DB >> 27809549

Chemical Synthesis of the Repeating Unit of Type V Group B Streptococcus Capsular Polysaccharide.

Jian Gao1, Zhongwu Guo2.   

Abstract

The first chemical synthesis of the heptasaccharide repeating unit of type V group B Streptococcus capsular polysaccharide (CPS) by a preactivation-based one-pot [2 + 1 + 4] glycosylation strategy is described. The synthetic efficiency was further improved by using diol glycosyl acceptors for regio-/stereoselective glycosylation reactions. The synthetic target contains a free amino group at the reducing end, facilitating additional regioselective elaboration. The results should be useful for synthetic and biological studies of related CPSs.

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Year:  2016        PMID： 27809549      PMCID： PMC5645073          DOI： 10.1021/acs.orglett.6b02796

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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