Mark A Louter1, Nadine Pelzer1, Irene de Boer1, Babette E C Kuijvenhoven1, Willebrordus P J van Oosterhout1, Erik W van Zwet1, Michel D Ferrari1, Gisela M Terwindt2. 1. From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands. 2. From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands. g.m.terwindt@lumc.nl.
Abstract
OBJECTIVE: To determine the prevalence of depression and determinants associated with depression in a large population of hemiplegic migraine (HM) patients. METHODS: We conducted a cross-sectional, validated questionnaire study among 89 well-defined HM patients and 235 headache-free controls. The prevalence of lifetime depression and its relation to migraine characteristics was assessed. RESULTS: HM patients had increased odds for lifetime depression (odds ratio 3.73, 95% confidence interval 2.18-6.38) compared with controls. Use of acute antimigraine medication was associated with lifetime depression. CONCLUSIONS: Depression is part of the monogenic hemiplegic migraine phenotype. Further studies are needed to elucidate the pathophysiologic role of HM genes in comorbid depression. For now, clinicians should take comorbid depression into consideration when starting prophylactic treatment of HM.
OBJECTIVE: To determine the prevalence of depression and determinants associated with depression in a large population of hemiplegic migraine (HM) patients. METHODS: We conducted a cross-sectional, validated questionnaire study among 89 well-defined HM patients and 235 headache-free controls. The prevalence of lifetime depression and its relation to migraine characteristics was assessed. RESULTS: HM patients had increased odds for lifetime depression (odds ratio 3.73, 95% confidence interval 2.18-6.38) compared with controls. Use of acute antimigraine medication was associated with lifetime depression. CONCLUSIONS:Depression is part of the monogenic hemiplegic migraine phenotype. Further studies are needed to elucidate the pathophysiologic role of HM genes in comorbid depression. For now, clinicians should take comorbid depression into consideration when starting prophylactic treatment of HM.
Authors: Eduardo Rivera-Mancilla; Linda Al-Hassany; Carlos M Villalón; Antoinette MaassenVanDenBrink Journal: Front Neurol Date: 2021-06-09 Impact factor: 4.003
Authors: Shahram Bahrami; Guy Hindley; Bendik Slagsvold Winsvold; Kevin S O'Connell; Oleksandr Frei; Alexey Shadrin; Weiqiu Cheng; Francesco Bettella; Linn Rødevand; Ketil J Odegaard; Chun C Fan; Matti J Pirinen; Heidi M Hautakangas; Anders M Dale; Srdjan Djurovic; Olav B Smeland; Ole A Andreassen Journal: Brain Date: 2022-03-29 Impact factor: 13.501