| Literature DB >> 27806869 |
Alicja Kalinowska-Łyszczarz1, Sławomir Michalak2, Mikołaj A Pawlak3, Jacek Losy4, Wojciech Kozubski5.
Abstract
Platelet-Endothelial-Cell-Adhesion-Molecule-1 (PECAM-1) and Human-Vascular-CAM-1 (VCAM-1) are adhesion molecules involved in leukocyte-endothelial interaction. In our study serum levels of sPECAM-1 and sVCAM-1 were measured (ELISA) in twenty-nine patients during their first monosymptomatic optic neuritis (ON) episode. Anti-aquaporin-4-antibodies (AQP4-IgG) were detected with the cell-based assay. Patients were followed for seven years, during which 16/24 AQP4-IgG (-) patients developed MS and 2/5 AQP4-IgG (+) patients developed NMO. Patients who developed MS had significantly lower sPECAM-1 and sVCAM-1 than those who did not. Serum sPECAM-1 and sVCAM-1 may turn out to be useful biomarkers correlated with the risk of progression to MS after first ON incident.Entities:
Keywords: Biomarkers; Human Vascular Cell Adhesion Molecule-1 (VCAM-1); Multiple sclerosis; Neuromyelitis optica; Optic neuritis; Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)
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Year: 2016 PMID： 27806869 DOI： 10.1016/j.jneuroim.2016.10.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478