| Literature DB >> 27806868 |
Qiuming Zeng1, Xiaohua Dong1, Chunyun Ruan1, Bo Hu1, Yuebei Luo1, Zhaohui Luo1, Liqun Xu1, Hao Zhou1, Runqi Wang1, Huan Yang2.
Abstract
The pathophysiologic significance of the CD16+ monocyte subset has been demonstrated by its expansion in various autoimmune disorders. To date, the characteristics and roles of monocyte subpopulations in patients with neuromyelitis optica (NMO) have been poorly defined. We measured the percentages of the monocyte subsets in the peripheral blood, the levels of IL-1β and TNF-α mRNA in monocyte subsets and the concentrations of IL-1β and TNF-α in plasma and CSF from NMO patients. Our results showed that nonclassical monocytes were up-regulated in NMO patients and significantly elevated IL-1β and TNF-α expression was detected in it. In addition the increased nonclassical monocytes could be selectively suppressed by GC in patients with NMO.Entities:
Keywords: Flow cytometry; Glucocorticoids; Interleukin-1beta; Monocyte subsets; Neuromyelitis optica; Tumor necrosis factor-alpha
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Year: 2016 PMID： 27806868 DOI： 10.1016/j.jneuroim.2016.09.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478