Sergio Della Sala1,2, Irina Kozlova1, Andreea Stamate1, Mario A Parra2,3,4,5,6,7. 1. Human Cognitive Neuroscience, Psychology Department, University of Edinburgh, UK. 2. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK. 3. School of Social Sciences, Psychology, University Heriot-Watt, UK. 4. Scottish Dementia Clinical Research Network, NHS Scotland, UK. 5. Alzheimer's Scotland Dementia Research Centre, UK. 6. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Psychology, Chile. 7. Universidad Autónoma del Caribe, Barranquilla, Colombia.
Abstract
OBJECTIVE: Temporary binding (TB) is sensitive and specific to Alzheimer's Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerised version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version. METHODS: A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1, this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the new TB test and with Free and Cued Selective Reminding test. RESULTS: The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age, but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test. CONCLUSIONS: TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive, and facilitates cross-cultural studies.
OBJECTIVE: Temporary binding (TB) is sensitive and specific to Alzheimer's Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerised version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version. METHODS: A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1, this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the new TB test and with Free and Cued Selective Reminding test. RESULTS: The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age, but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test. CONCLUSIONS: TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive, and facilitates cross-cultural studies.
Authors: Leslie S Gaynor; Sarah A Johnson; Jack Morgan Mizell; Keila T Campos; Andrew P Maurer; Russell M Bauer; Sara N Burke Journal: Behav Neurosci Date: 2018-06 Impact factor: 1.912
Authors: Jessica R Petok; Catherine E Myers; Judy Pa; Zachary Hobel; David M Wharton; Luis D Medina; Maria Casado; Giovanni Coppola; Mark A Gluck; John M Ringman Journal: Neurobiol Aging Date: 2018-02-08 Impact factor: 5.133
Authors: Maria C Valdés Hernández; Rupert Clark; Szu-Han Wang; Federica Guazzo; Clara Calia; Vivek Pattan; John Starr; Sergio Della Sala; Mario Alfredo Parra Journal: Neuroimage Clin Date: 2019-12-29 Impact factor: 4.881
Authors: Mario Amore Cecchini; Mônica Sanches Yassuda; Valéria Santoro Bahia; Leonardo Cruz de Souza; Henrique Cerqueira Guimarães; Paulo Caramelli; Maria Teresa Carthery-Goulart; Flávia Patrocínio; Maria Paula Foss; Vitor Tumas; Thaís Bento Lima-Silva; Sônia Maria Dozzi Brucki; Ricardo Nitrini; Sergio Della Sala; Mario A Parra Journal: J Neurol Date: 2017-09-11 Impact factor: 4.849
Authors: Pierre-Yves Jonin; Clara Calia; Sophie Muratot; Serge Belliard; Quentin Duché; Emmanuel J Barbeau; Mario A Parra Journal: Cortex Date: 2018-08-27 Impact factor: 4.027