| Literature DB >> 2780509 |
J M Warnet1, M O Christen, M Thevenin, D Biard, A Jacqueson, J R Claude.
Abstract
Anethol dithiolthione (ADT), usually prescribed as a choleretic drug, when given orally 1 hour prior to acetaminophen (AAP) (450 mg/kg intraperitoneally) in Swiss female mice, exhibited an hepatoprotective potency at doses as low as 10 mg/kg relative to serum aminotransferase activities and hepatic glutathione related enzyme system (glutathione reductase, peroxidase, transferase). These preliminary results are relevant with the use of pharmacologic dosage of ADT in hepatotoxicity prevention.Entities:
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Year: 1989 PMID： 2780509 DOI： 10.1111/j.1600-0773.1989.tb01127.x
Source DB: PubMed Journal: Pharmacol Toxicol ISSN： 0901-9928