Eunice Y Chen1, Thomas M Olino2, Chris J Conklin3,4, Feroze B Mohamed3,4, W Scott Hoge5, Gary D Foster6,7,8, Jean M Arlt1, Kalina Eneva1, Judy R Kidd9, Kenneth R Kidd9, Michelle R Lent10, Susan Murray1, Andrew Newberg11, Colleen Tewksbury12, Stephanie S VanderVeur7, Angelina Yiu1. 1. Temple Eating Disorders program (TEDp), Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA. 2. Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA. 3. Temple University Magnetic Resonance Imaging Center, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA. 4. Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. 5. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA. 6. Center for Obesity Research and Education, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA. 7. Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 8. Weight Watchers International Inc., New York, New York, USA. 9. Department of Genetics, Yale University, New Haven, Connecticut, USA. 10. Department of Psychiatry, Geisinger Obesity Institute, Danville, Pennsylvania, USA. 11. Myrna Brind Center of Integrative Medicine, Department of Radiology, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania, USA. 12. Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVE: To examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL. METHODS: Neural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice using functional magnetic resonance imaging at baseline and 12 weeks. Weight was assessed at baseline, 12, 36, and 60 weeks. RESULTS: BWL participants lost more weight than controls at 12 weeks (-4.82% versus -0.70%). After 12 weeks, BWL had greater reduction in right caudate activation response to milk shake receipt than did controls. Among BWL participants, baseline to 12-week reduction in frontostriatal activation to milk shake predicted greater weight loss at 12, 36, and 60 weeks. Possessing the A/A or T/A genotype of the fat mass and obesity-associated (FTO) variant rs9939609 predicted greater weight loss at 12 and 36 weeks. CONCLUSIONS: These preliminary data reveal that reduction in right caudate activation may be a neural mechanism of weight loss in BWL, and baseline FTO variant and reduction in frontostriatal activation during BWL predict short- and long-term weight loss. These findings require replication in larger samples.
OBJECTIVE: To examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL. METHODS: Neural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice using functional magnetic resonance imaging at baseline and 12 weeks. Weight was assessed at baseline, 12, 36, and 60 weeks. RESULTS: BWL participants lost more weight than controls at 12 weeks (-4.82% versus -0.70%). After 12 weeks, BWL had greater reduction in right caudate activation response to milk shake receipt than did controls. Among BWL participants, baseline to 12-week reduction in frontostriatal activation to milk shake predicted greater weight loss at 12, 36, and 60 weeks. Possessing the A/A or T/A genotype of the fat mass and obesity-associated (FTO) variant rs9939609 predicted greater weight loss at 12 and 36 weeks. CONCLUSIONS: These preliminary data reveal that reduction in right caudate activation may be a neural mechanism of weight loss in BWL, and baseline FTO variant and reduction in frontostriatal activation during BWL predict short- and long-term weight loss. These findings require replication in larger samples.
Authors: Keri L Monda; Gary K Chen; Kira C Taylor; Cameron Palmer; Todd L Edwards; Leslie A Lange; Maggie C Y Ng; Adebowale A Adeyemo; Matthew A Allison; Lawrence F Bielak; Guanjie Chen; Mariaelisa Graff; Marguerite R Irvin; Suhn K Rhie; Guo Li; Yongmei Liu; Youfang Liu; Yingchang Lu; Michael A Nalls; Yan V Sun; Mary K Wojczynski; Lisa R Yanek; Melinda C Aldrich; Adeyinka Ademola; Christopher I Amos; Elisa V Bandera; Cathryn H Bock; Angela Britton; Ulrich Broeckel; Quiyin Cai; Neil E Caporaso; Chris S Carlson; John Carpten; Graham Casey; Wei-Min Chen; Fang Chen; Yii-Der I Chen; Charleston W K Chiang; Gerhard A Coetzee; Ellen Demerath; Sandra L Deming-Halverson; Ryan W Driver; Patricia Dubbert; Mary F Feitosa; Ye Feng; Barry I Freedman; Elizabeth M Gillanders; Omri Gottesman; Xiuqing Guo; Talin Haritunians; Tamara Harris; Curtis C Harris; Anselm J M Hennis; Dena G Hernandez; Lorna H McNeill; Timothy D Howard; Barbara V Howard; Virginia J Howard; Karen C Johnson; Sun J Kang; Brendan J Keating; Suzanne Kolb; Lewis H Kuller; Abdullah Kutlar; Carl D Langefeld; Guillaume Lettre; Kurt Lohman; Vaneet Lotay; Helen Lyon; Joann E Manson; William Maixner; Yan A Meng; Kristine R Monroe; Imran Morhason-Bello; Adam B Murphy; Josyf C Mychaleckyj; Rajiv Nadukuru; Katherine L Nathanson; Uma Nayak; Amidou N'diaye; Barbara Nemesure; Suh-Yuh Wu; M Cristina Leske; Christine Neslund-Dudas; Marian Neuhouser; Sarah Nyante; Heather Ochs-Balcom; Adesola Ogunniyi; Temidayo O Ogundiran; Oladosu Ojengbede; Olufunmilayo I Olopade; Julie R Palmer; Edward A Ruiz-Narvaez; Nicholette D Palmer; Michael F Press; Evandine Rampersaud; Laura J Rasmussen-Torvik; Jorge L Rodriguez-Gil; Babatunde Salako; Eric E Schadt; Ann G Schwartz; Daniel A Shriner; David Siscovick; Shad B Smith; Sylvia Wassertheil-Smoller; Elizabeth K Speliotes; Margaret R Spitz; Lara Sucheston; Herman Taylor; Bamidele O Tayo; Margaret A Tucker; David J Van Den Berg; Digna R Velez Edwards; Zhaoming Wang; John K Wiencke; Thomas W Winkler; John S Witte; Margaret Wrensch; Xifeng Wu; James J Yang; Albert M Levin; Taylor R Young; Neil A Zakai; Mary Cushman; Krista A Zanetti; Jing Hua Zhao; Wei Zhao; Yonglan Zheng; Jie Zhou; Regina G Ziegler; Joseph M Zmuda; Jyotika K Fernandes; Gary S Gilkeson; Diane L Kamen; Kelly J Hunt; Ida J Spruill; Christine B Ambrosone; Stefan Ambs; Donna K Arnett; Larry Atwood; Diane M Becker; Sonja I Berndt; Leslie Bernstein; William J Blot; Ingrid B Borecki; Erwin P Bottinger; Donald W Bowden; Gregory Burke; Stephen J Chanock; Richard S Cooper; Jingzhong Ding; David Duggan; Michele K Evans; Caroline Fox; W Timothy Garvey; Jonathan P Bradfield; Hakon Hakonarson; Struan F A Grant; Ann Hsing; Lisa Chu; Jennifer J Hu; Dezheng Huo; Sue A Ingles; Esther M John; Joanne M Jordan; Edmond K Kabagambe; Sharon L R Kardia; Rick A Kittles; Phyllis J Goodman; Eric A Klein; Laurence N Kolonel; Loic Le Marchand; Simin Liu; Barbara McKnight; Robert C Millikan; Thomas H Mosley; Badri Padhukasahasram; L Keoki Williams; Sanjay R Patel; Ulrike Peters; Curtis A Pettaway; Patricia A Peyser; Bruce M Psaty; Susan Redline; Charles N Rotimi; Benjamin A Rybicki; Michèle M Sale; Pamela J Schreiner; Lisa B Signorello; Andrew B Singleton; Janet L Stanford; Sara S Strom; Michael J Thun; Mara Vitolins; Wei Zheng; Jason H Moore; Scott M Williams; Shamika Ketkar; Xiaofeng Zhu; Alan B Zonderman; Charles Kooperberg; George J Papanicolaou; Brian E Henderson; Alex P Reiner; Joel N Hirschhorn; Ruth J F Loos; Kari E North; Christopher A Haiman Journal: Nat Genet Date: 2013-04-14 Impact factor: 38.330
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