Literature DB >> 27804130

Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.

E Cocucci1, J Y Kim2, Y Bai2, N Pabla2.   

Abstract

Intracellular drug accumulation is thought to be dictated by two major processes, passive diffusion through the lipid membrane or membrane transporters. The relative role played by these distinct processes remains actively debated. Moreover, the role of membrane-trafficking in drug transport remains underappreciated and unexplored. Here we discuss the distinct processes involved in cellular drug distribution and propose that better experimental models are required to elucidate the differential contributions of various processes in intracellular drug accumulation.
© 2016 American Society for Clinical Pharmacology and Therapeutics.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27804130     DOI： 10.1002/cpt.545

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  9 in total

1.  Clinical Pharmacology & Therapeutics: Past, Present, and Future.

Authors:  S A Waldman; A Terzic
Journal:  Clin Pharmacol Ther       Date:  2017-03       Impact factor: 6.875

Review 2.  The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.

Authors:  Sanjay K Nigam
Journal:  Annu Rev Pharmacol Toxicol       Date:  2018-01-06       Impact factor: 13.820

3.  Lipid Head Group Parameterization for GROMOS 54A8: A Consistent Approach with Protein Force Field Description.

Authors:  Irene Marzuoli; Christian Margreitter; Franca Fraternali
Journal:  J Chem Theory Comput       Date:  2019-09-09       Impact factor: 6.006

4.  Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane.

Authors:  Renu Wadhwa; Neetu Singh Yadav; Shashank P Katiyar; Tomoko Yaguchi; Chohee Lee; Hyomin Ahn; Chae-Ok Yun; Sunil C Kaul; Durai Sundar
Journal:  Sci Rep       Date:  2021-01-27       Impact factor: 4.379

Review 5.  Frameworks for targeting RNA with small molecules.

Authors:  Aline Umuhire Juru; Amanda E Hargrove
Journal:  J Biol Chem       Date:  2020-12-20       Impact factor: 5.157

6.  Symmetry disruption commits vault particles to disassembly.

Authors:  Pablo Guerra; María González-Alamos; Aida Llauró; Arnau Casañas; Jordi Querol-Audí; Pedro J de Pablo; Núria Verdaguer
Journal:  Sci Adv       Date:  2022-02-09       Impact factor: 14.136

7.  Improving Drug Sensitivity of HIV-1 Protease Inhibitors by Restriction of Cellular Efflux System in a Fission Yeast Model.

Authors:  Jiantao Zhang; Qi Li; Shigehiro A Kawashima; Mohamed Nasr; Fengtian Xue; Richard Y Zhao
Journal:  Pathogens       Date:  2022-07-16

8.  Multiscale modelling of drug transport and metabolism in liver spheroids.

Authors:  Joseph A Leedale; Jonathan A Kyffin; Amy L Harding; Helen E Colley; Craig Murdoch; Parveen Sharma; Dominic P Williams; Steven D Webb; Rachel N Bearon
Journal:  Interface Focus       Date:  2020-02-14       Impact factor: 3.906

9.  Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells.

Authors:  Alessandra Nigro; Luca Frattaruolo; Mariarosa Fava; Ilaria De Napoli; Marianna Greco; Alessandra Comandè; Marzia De Santo; Michele Pellegrino; Elena Ricci; Francesca Giordano; Ida Perrotta; Antonella Leggio; Luigi Pasqua; Diego Sisci; Anna Rita Cappello; Catia Morelli
Journal:  Cancers (Basel)       Date:  2020-09-21       Impact factor: 6.639
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.