Mukedaisi Abulizi1,2, Anne-Ségolène Cottereau1,2,3, Aziz Guellich1,3,4,5, Stéphanie Vandeventer1,2, Arnault Galat1,3,4,5, Axel Van Der Gucht1,2, Violaine Plante-Bordeneuve1,3,5,6, Jean-Luc Dubois-Randé1,3,4,5, Diane Bodez1,3,4,5, Jean Rosso1,2,3, Thibaud Damy1,3,4,5, Emmanuel Itti7,8,9,10. 1. Mondor Amyloidosis Network, 94000, Créteil, France. 2. Department of Nuclear Medicine, AP-HP, Henri Mondor Hospital, 94000, Créteil, France. 3. DHU ATVB, Paris Est University, 94000, Créteil, France. 4. Department of Cardiology, AP-HP, Henri Mondor Hospital, 51 Ave. du Mal de Lattre de Tassigny, 94000, Créteil, France. 5. INSERM U955, GRC Amyloid Research Institute, 94000, Créteil, France. 6. Department of Neurology, AP-HP, Henri Mondor Hospital, 94000, Créteil, France. 7. Mondor Amyloidosis Network, 94000, Créteil, France. emmanuel.itti@aphp.fr. 8. Department of Nuclear Medicine, AP-HP, Henri Mondor Hospital, 94000, Créteil, France. emmanuel.itti@aphp.fr. 9. DHU ATVB, Paris Est University, 94000, Créteil, France. emmanuel.itti@aphp.fr. 10. INSERM U955, GRC Amyloid Research Institute, 94000, Créteil, France. emmanuel.itti@aphp.fr.
Abstract
BACKGROUND: This study sought to compare the intensity of early-phase myocardial uptake of two phosphonate-based radiotracers, 99mTc-hydroxymethylene diphosphonate (HMDP) and 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), in patients with hereditary transthyretin-related cardiac amyloidosis (TTR-CA). METHODS: Six patients with biopsy-proven diagnosis of TTR-CA and characteristic amyloid fibril composition underwent early-phase 99mTc-HMDP myocardial scintigraphy as part of their routine workup; they were later assessed by 99mTc-DPD scintigraphy after having signed informed written consent. Heart-to-mediastinum-ratio was measured at both time points as well as regional distribution on 17-segment analysis. RESULTS: All patients had an H/M ratio >1.28 on both imaging. 99mTc-DPD uptake was slightly higher than 99mTc-HMDP uptake in 3 patients, but no statistical difference was found (P = 0.13). Regional distribution of the two radiotracers was well correlated on bull's eyes analysis, with only slight underestimation of 99mTc-DPD uptake in the anterior/apical segments, compared with 99mTc-HMDP. CONCLUSION: 99mTc-HMDP and 99mTc-DPD show comparable myocardial uptake intensity on early-phase scintigraphy and can be used alternatively for the diagnosis of TTR-CA.
BACKGROUND: This study sought to compare the intensity of early-phase myocardial uptake of two phosphonate-based radiotracers, 99mTc-hydroxymethylene diphosphonate (HMDP) and 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), in patients with hereditary transthyretin-related cardiac amyloidosis (TTR-CA). METHODS: Six patients with biopsy-proven diagnosis of TTR-CA and characteristic amyloid fibril composition underwent early-phase 99mTc-HMDP myocardial scintigraphy as part of their routine workup; they were later assessed by 99mTc-DPD scintigraphy after having signed informed written consent. Heart-to-mediastinum-ratio was measured at both time points as well as regional distribution on 17-segment analysis. RESULTS: All patients had an H/M ratio >1.28 on both imaging. 99mTc-DPD uptake was slightly higher than 99mTc-HMDP uptake in 3 patients, but no statistical difference was found (P = 0.13). Regional distribution of the two radiotracers was well correlated on bull's eyes analysis, with only slight underestimation of 99mTc-DPD uptake in the anterior/apical segments, compared with 99mTc-HMDP. CONCLUSION:99mTc-HMDP and 99mTc-DPD show comparable myocardial uptake intensity on early-phase scintigraphy and can be used alternatively for the diagnosis of TTR-CA.
Entities:
Keywords:
99mTc-DPD; 99mTc-HMDP; Transthyretin-related cardiac amyloidosis; early phase; myocardial uptake
Authors: Dorota M Rowczenio; Islam Noor; Julian D Gillmore; Helen J Lachmann; Carol Whelan; Philip N Hawkins; Laura Obici; Per Westermark; Gilles Grateau; Ashutosh D Wechalekar Journal: Hum Mutat Date: 2014-08-04 Impact factor: 4.878
Authors: David F Hutt; Anne-Marie Quigley; Joanne Page; Margaret L Hall; Maria Burniston; Dorothea Gopaul; Thirusha Lane; Carol J Whelan; Helen J Lachmann; Julian D Gillmore; Philip N Hawkins; Ashutosh D Wechalekar Journal: Eur Heart J Cardiovasc Imaging Date: 2014-06-16 Impact factor: 6.875
Authors: Adam Castaño; Albert DeLuca; Richard Weinberg; Ted Pozniakoff; William S Blaner; Altaf Pirmohamed; Brian Bettencourt; Jared Gollob; Verena Karsten; John A Vest; Codruta Chiuzan; Mathew S Maurer; Sabahat Bokhari Journal: J Nucl Cardiol Date: 2015-10-09 Impact factor: 5.952
Authors: Sharmila Dorbala; Yukio Ando; Sabahat Bokhari; Angela Dispenzieri; Rodney H Falk; Victor A Ferrari; Marianna Fontana; Olivier Gheysens; Julian D Gillmore; Andor W J M Glaudemans; Mazen A Hanna; Bouke P C Hazenberg; Arnt V Kristen; Raymond Y Kwong; Mathew S Maurer; Giampaolo Merlini; Edward J Miller; James C Moon; Venkatesh L Murthy; C Cristina Quarta; Claudio Rapezzi; Frederick L Ruberg; Sanjiv J Shah; Riemer H J A Slart; Hein J Verberne; Jamieson M Bourque Journal: J Nucl Cardiol Date: 2019-12 Impact factor: 5.952
Authors: Giorgio Treglia; Andor W J M Glaudemans; Francesco Bertagna; Bouke P C Hazenberg; Paola A Erba; Raffaele Giubbini; Luca Ceriani; John O Prior; Luca Giovanella; Riemer H J A Slart Journal: Eur J Nucl Med Mol Imaging Date: 2018-04-23 Impact factor: 9.236
Authors: Teodor M Ionescu; Wael Jalloul; Cati R Stolniceanu; Roxana Iacob; Laura P Grecu; Ana-Maria Stătescu; Irena Grierosu; Mihai Guțu; Adrian Gavrilescu; Crișu Daniela; Antoniu Petriș; Manuela Ciocoiu; Cristina Ungureanu; Cipriana Ștefănescu Journal: Ann Nucl Med Date: 2021-07-17 Impact factor: 2.668