Literature DB >> 27803873

Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma.

Ugur Yilmaz Mumcu1, Ibrahim Kocer2, Orhan Ates2, H Hakan Alp3.   

Abstract

To investigate the malondialdehyde (MDA) levels, paraoxonase1 (PON1) activity and 8-hydroxy 2-deoxyguanosine (8-OHdG) levels in the primary open angle glaucoma (POAG) patient. Blood samples from 52 healthy individuals and 53 patients with POAG were analyzed for MDA and 8-OHdG by HPLC (high-performance liquid chromatography) and PON1 by spectrophotometry. The data obtained were analyzed statistically. MDA levels were 10.46±8.4 and 4.70±1.79 µmol; PON1 levels were 121±39.55 and 161.62±60.22 U/mL; and 8-OHdG values were 1.32±0.53/106 dG and 0.47±0.27/106 dG in the POAG patients and the control group, respectively. The difference was significant in MDA levels, 8-OHdG levels and PON1 activity in POAG patients in comparison with controls (P<0.001). We concluded that the observed increase in MDA and 8-OHdG levels may be correlated with decreased PON1 activity. Oxidative stress plays an important role in glaucoma development.

Entities:  

Keywords:  8-hydroxy 2-deoxyguanosine; glaucoma; paraoxonase

Year:  2016        PMID： 27803873      PMCID： PMC5075671          DOI： 10.18240/ijo.2016.10.24

Source DB:  PubMed          Journal:  Int J Ophthalmol        ISSN： 2222-3959            Impact factor:   1.779


  15 in total

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Review 3.  [Oxidative stress in the trabecular meshwork of POAG].

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4.  A two-year follow-up of oral antioxidant supplementation in primary open-angle glaucoma: an open-label, randomized, controlled trial.

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7.  Increased urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG)/creatinine level is associated with the progression of normal-tension glaucoma.

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Journal:  Curr Eye Res       Date:  2013-06-14       Impact factor: 2.424

8.  Oxidative DNA damage in retinopathy of prematurity.

Authors:  O Ates; H H Alp; I Caner; A Yildirim; A Tastekin; I Kocer; O Baykal
Journal:  Eur J Ophthalmol       Date:  2009 Jan-Feb       Impact factor: 2.597

9.  Oxidative stress markers in aqueous humor of glaucoma patients.

Authors:  Sandra M Ferreira; S Fabián Lerner; R Brunzini; Pablo A Evelson; Susana F Llesuy
Journal:  Am J Ophthalmol       Date:  2004-01       Impact factor: 5.258

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6.  Paraoxonase 1 (PON1) promoter (-107T/C) and coding region (192Q/R and 55L/M) genetic variations in pseudoexfoliation syndrome and pseudoexfoliative glaucoma risk.

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8.  Elevated Plasma Level of 8-Hydroxy-2'-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma.

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Review 9.  Strategies to Reduce Oxidative Stress in Glaucoma Patients.

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10.  Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma.

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  10 in total

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