Literature DB >> 27802223

Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.

Richard McClure1,2,3, Henry Ong1,2, Vaibhab Janve1,2, Shawn Barton1,2, Meiying Zhu1,2, Bo Li1,2, Mary Dawes4, W Gray Jerome5, Adam Anderson1,2,6, Pierre Massion7, John C Gore1,2,6,3, Wellington Pham1,2,6,7,8,3.   

Abstract

We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.

Entities:  

Keywords:  Aerosol; amyloid-β; curcumin; nebulization

Mesh：

Substances：

Year:  2017        PMID： 27802223      PMCID： PMC5848215          DOI： 10.3233/JAD-160289

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  45 in total

1.  Beta-amyloid plaques induce neuritic dystrophy of nitric oxide-producing neurons in a transgenic mouse model of Alzheimer's disease.

Authors:  J Quinn; F Davis; W R Woodward; F Eckenstein
Journal:  Exp Neurol       Date:  2001-04       Impact factor: 5.330

2.  Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-κB signalling in lymphoma-bearing mice.

Authors:  Laxmidhar Das; Manjula Vinayak
Journal:  Biosci Rep       Date:  2012-04-01       Impact factor: 3.840

Review 3.  Comparative anatomy of the prosubiculum, subiculum, presubiculum, postsubiculum, and parasubiculum in human, monkey, and rodent.

Authors:  Song-Lin Ding
Journal:  J Comp Neurol       Date:  2013-12-15       Impact factor: 3.215

4.  Strategy and planning for chemopreventive drug development: clinical development plans II.

Authors:  G J Kelloff; J A Crowell; E T Hawk; V E Steele; R A Lubet; C W Boone; J M Covey; L A Doody; G S Omenn; P Greenwald; W K Hong; D R Parkinson; D Bagheri; G T Baxter; M Blunden; M K Doeltz; K M Eisenhauer; K Johnson; G G Knapp; D G Longfellow; W F Malone; S G Nayfield; H E Seifried; L M Swall; C C Sigman
Journal:  J Cell Biochem Suppl       Date:  1996

5.  Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects.

Authors:  Esther Parada; Izaskun Buendia; Elisa Navarro; Carlos Avendaño; Javier Egea; Manuela G López
Journal:  Mol Nutr Food Res       Date:  2015-06-30       Impact factor: 5.914

Review 6.  The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update.

Authors:  Shatadal Ghosh; Sharmistha Banerjee; Parames C Sil
Journal:  Food Chem Toxicol       Date:  2015-06-09       Impact factor: 6.023

7.  Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.

Authors:  Laura Trujillo-Estrada; José Carlos Dávila; Elisabeth Sánchez-Mejias; Raquel Sánchez-Varo; Angela Gomez-Arboledas; Marisa Vizuete; Javier Vitorica; Antonia Gutiérrez
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

8.  An autoradiographic study of complementary laminar patterns of termination of afferent fibers to the olfactory cortex.

Authors:  J L Price
Journal:  J Comp Neurol       Date:  1973-07-01       Impact factor: 3.215

9.  A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

Authors:  C A Davies; D M Mann; P Q Sumpter; P O Yates
Journal:  J Neurol Sci       Date:  1987-04       Impact factor: 3.181

10.  Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry.

Authors:  Richard A McClure; Chad W Chumbley; Michelle L Reyzer; Kevin Wilson; Richard M Caprioli; John C Gore; Wellington Pham
Journal:  Neuroimage Clin       Date:  2013-04-30       Impact factor: 4.881
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  16 in total

1.  A Curcumin Degradation Product, 7-Norcyclopentadione, Formed by Aryl Migration and Loss of a Carbon from the Heptadienedione Chain.

Authors:  Akil I Joseph; Paula B Luis; Claus Schneider
Journal:  J Nat Prod       Date:  2018-12-18       Impact factor: 4.050

2.  Effects of Deuteration of 13C-Enriched Phospholactate on Efficiency of Parahydrogen-Induced Polarization by Magnetic Field Cycling.

Authors:  Oleg G Salnikov; Roman V Shchepin; Nikita V Chukanov; Lamya Jaigirdar; Wellington Pham; Kirill V Kovtunov; Igor V Koptyug; Eduard Y Chekmenev
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2018-10-02       Impact factor: 4.126

3.  Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer's Disease Mouse Model.

Authors:  Lin Lin; Cheng Li; Deyi Zhang; Mingxiang Yuan; Chun-Hai Chen; Maoquan Li
Journal:  Neurochem Res       Date:  2020-02-21       Impact factor: 3.996

4.  Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.

Authors:  Marco Cocorocchio; Amy J Baldwin; Balint Stewart; Lou Kim; Adrian J Harwood; Christopher R L Thompson; Paul L R Andrews; Robin S B Williams
Journal:  Dis Model Mech       Date:  2018-01-29       Impact factor: 5.758

Review 5.  Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?

Authors:  Jeffrey R Liddell
Journal:  Antioxidants (Basel)       Date:  2017-08-18

Review 6.  Curcumin's Nanomedicine Formulations for Therapeutic Application in Neurological Diseases.

Authors:  Bahare Salehi; Daniela Calina; Anca Oana Docea; Niranjan Koirala; Sushant Aryal; Domenico Lombardo; Luigi Pasqua; Yasaman Taheri; Carla Marina Salgado Castillo; Miquel Martorell; Natália Martins; Marcello Iriti; Hafiz Ansar Rasul Suleria; Javad Sharifi-Rad
Journal:  J Clin Med       Date:  2020-02-05       Impact factor: 4.241

7.  A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.

Authors:  Ju-Xian Song; Sandeep Malampati; Yu Zeng; Siva Sundara Kumar Durairajan; Chuan-Bin Yang; Benjamin Chun-Kit Tong; Ashok Iyaswamy; Wen-Bin Shang; Sravan Gopalkrishnashetty Sreenivasmurthy; Zhou Zhu; King-Ho Cheung; Jia-Hong Lu; Chunzhi Tang; Nenggui Xu; Min Li
Journal:  Aging Cell       Date:  2019-12-19       Impact factor: 9.304

8.  Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Authors:  Maja Hullmann; Catrin Albrecht; Damiën van Berlo; Miriam E Gerlofs-Nijland; Tina Wahle; Agnes W Boots; Jean Krutmann; Flemming R Cassee; Thomas A Bayer; Roel P F Schins
Journal:  Part Fibre Toxicol       Date:  2017-08-30       Impact factor: 9.400

Review 9.  Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases.

Authors:  Palanivel Ganesan; Prakash Ramalingam; Govindarajan Karthivashan; Young Tag Ko; Dong-Kug Choi
Journal:  Int J Nanomedicine       Date:  2018-03-15

10.  Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer's Disease.

Authors:  Yan Liu; Ting Du; Wenlong Zhang; Weiye Lu; Zhichao Peng; Shuqiong Huang; Xiangdong Sun; Xiaoqin Zhu; Chaojun Chen; Linchao Qian; Lei Wen; Pingyi Xu; Yunlong Zhang
Journal:  Oxid Med Cell Longev       Date:  2019-11-03       Impact factor: 6.543
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