| Literature DB >> 27799354 |
Christine Dahlke1,2, Sebastian Lunemann3, Rahel Kasonta1,2, Benno Kreuels1, Stefan Schmiedel1, My L Ly1,2, Sarah K Fehling4,5, Thomas Strecker4,5, Stephan Becker4,5, Marcus Altfeld6,2, Abdourahmane Sow7, Ansgar W Lohse1,2, César Muñoz-Fontela3, Marylyn M Addo1,2.
Abstract
The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.Entities:
Keywords: EVD; EVD survivor; Ebola GP–specific T-cell responses; T-cell activation; cellular immune response; convalescent phase; lymphocyte dynamics; polyfunctional T-cell responses
Mesh：
Year: 2017 PMID： 27799354 DOI： 10.1093/infdis/jiw508
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226