Literature DB >> 27799219

Acinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium.

Federica Runci1, Carlo Bonchi1, Emanuela Frangipani1, Daniela Visaggio1, Paolo Visca2.   

Abstract

Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reduces A. baumannii growth and biofilm formation in HS, whereas 64 μM GaN causes massive disruption of preformed A. baumannii biofilm. These findings pave the way to the repurposing of GaN as an antibiofilm agent for A. baumannii.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  Acinetobacter baumannii; biofilm; gallium; iron; iron metabolism; serum

Mesh：

Substances：

Year:  2016        PMID： 27799219      PMCID： PMC5192145          DOI： 10.1128/AAC.01563-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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