Alen Bišćanin1, Neven Ljubičić2, Marko Boban3,4, Drinko Baličević5, Ivana Pavić5, Mirela Maver Bišćanin6, Ivan Budimir2, Zdravko Dorosulic2, Marko Duvnjak2. 1. Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia alen.biscanin@gmail.com. 2. Division of Gastroenterology, Department of Internal Medicine, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia. 3. Department of Cardiology, University Hospital Thalassotherapia Opatija, Medical Faculty University of Rijeka, Opatija, Croatia. 4. Department of Internal Medicine, University Hospital Osijek, Medical Faculty JJ Strossmayer University of Osijek, Osijek, Croatia. 5. Ljudevit Jurak University Department of Pathology, University Hospital Centre Sestre Milosrdnice, University of Zagreb School of Medicine and University of Zagreb School of Dental Medicine, Zagreb, Croatia. 6. Department of Prosthodontics, Zagreb Dental Clinic, Zagreb, Croatia.
Abstract
BACKGROUND/AIM: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. PATIENTS AND METHODS: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. RESULTS: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). CONCLUSION: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level. Copyright
BACKGROUND/AIM: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. PATIENTS AND METHODS: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. RESULTS:CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). CONCLUSION:CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level. Copyright
Authors: Yue Guo; Renyi Wu; John M Gaspar; Davit Sargsyan; Zheng-Yuan Su; Chengyue Zhang; Linbo Gao; David Cheng; Wenji Li; Chao Wang; Ran Yin; Mingzhu Fang; Michael P Verzi; Ronald P Hart; Ah-Ng Kong Journal: Carcinogenesis Date: 2018-05-03 Impact factor: 4.944