Juliana Knief1, Katharina Reddemann2, Ekaterina Petrova3, Tobias Herhahn2, Ulrich Wellner3, Christoph Thorns2. 1. Department of Pathology, Section of Hematopathology and Endocrine Pathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany Juliana.Knief@uksh.de. 2. Department of Pathology, Section of Hematopathology and Endocrine Pathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. 3. Department of Surgery, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Abstract
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell infiltration is commonly associated with improved survival. MATERIALS AND METHODS: We assessed the density of tumor-infiltrating B-cells, as well as that of plasma cells, in 210 adenocarcinomas of the esophagogastric junction through immunohistochemical analysis using antibodies against CD20 and CD138. RESULTS: No correlation between density of B-cells or plasma cells and various clinicopathologic features could be established. High density of tumor-infiltrating B-cells, as well as plasma cells, showed significantly better overall survival (OS) compared to patients with no infiltrates (p=0.047 and p=0.022, respectively). Cox proportional hazard analysis could verify B-cell infiltration as an independent prognostic factor (hazard ratio (HR)=0.683; 95% confidence interval (CI)=0.517-0.901; p=0.007). CONCLUSION: Plasma cell and B-cell infiltration correlates with prolonged OS and might identify a patient subset with favorable disease course. Copyright
BACKGROUND:Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell infiltration is commonly associated with improved survival. MATERIALS AND METHODS: We assessed the density of tumor-infiltrating B-cells, as well as that of plasma cells, in 210 adenocarcinomas of the esophagogastric junction through immunohistochemical analysis using antibodies against CD20 and CD138. RESULTS: No correlation between density of B-cells or plasma cells and various clinicopathologic features could be established. High density of tumor-infiltrating B-cells, as well as plasma cells, showed significantly better overall survival (OS) compared to patients with no infiltrates (p=0.047 and p=0.022, respectively). Cox proportional hazard analysis could verify B-cell infiltration as an independent prognostic factor (hazard ratio (HR)=0.683; 95% confidence interval (CI)=0.517-0.901; p=0.007). CONCLUSION: Plasma cell and B-cell infiltration correlates with prolonged OS and might identify a patient subset with favorable disease course. Copyright
Authors: William S Chen; Winston A Haynes; Rebecca Waitz; David Y Oh; John C Shon; Felix Y Feng; Kathy Kamath; Agustin Vega-Crespo; Raunak Shrestha; Minlu Zhang; Adam Foye; Ignacio Baselga Carretero; Ivan Perez Garcilazo; Meng Zhang; Shuang G Zhao; Martin Sjöström; David A Quigley; Jonathan Chou; Tomasz M Beer; Matthew Rettig; Martin Gleave; Christopher P Evans; Primo Lara; Kim N Chi; Robert E Reiter; Joshi J Alumkal; Alan Ashworth; Rahul Aggarwal; Eric J Small; Patrick S Daugherty; Antoni Ribas Journal: Clin Cancer Res Date: 2020-09-23 Impact factor: 12.531