PURPOSE OF REVIEW: Review of recent literature pertaining to frequency, associations, mechanisms, and overall significance of sleep--wake disturbances (SWD) in the premotor and early phase of Parkinson's disease. RECENT FINDINGS: SWD are frequent in Parkinson's disease and their prevalence increases with disease progression. Recent studies confirm previous findings that SWD can appear as initial manifestation of Parkinson's disease even decades before motor signs appear and highlight their clinical associations in these early stages. More intriguingly, new evidence underpins their role as risk factors, predictors, or even as driving force for the neurodegenerative process. As our understanding of sleep--wake neurobiology increases, new hypotheses emerge concerning the pathophysiology of SWD in early Parkinson's disease stages involving dopaminergic and nondopaminergic mechanisms. SUMMARY: SWD are predictors for the development of parkinsonian syndromes including Parkinson's disease. This may offer the opportunity of developing new preventive strategies and interventions at an early stage of this neurodegenerative disease.
PURPOSE OF REVIEW: Review of recent literature pertaining to frequency, associations, mechanisms, and overall significance of sleep--wake disturbances (SWD) in the premotor and early phase of Parkinson's disease. RECENT FINDINGS: SWD are frequent in Parkinson's disease and their prevalence increases with disease progression. Recent studies confirm previous findings that SWD can appear as initial manifestation of Parkinson's disease even decades before motor signs appear and highlight their clinical associations in these early stages. More intriguingly, new evidence underpins their role as risk factors, predictors, or even as driving force for the neurodegenerative process. As our understanding of sleep--wake neurobiology increases, new hypotheses emerge concerning the pathophysiology of SWD in early Parkinson's disease stages involving dopaminergic and nondopaminergic mechanisms. SUMMARY: SWD are predictors for the development of parkinsonian syndromes including Parkinson's disease. This may offer the opportunity of developing new preventive strategies and interventions at an early stage of this neurodegenerative disease.
Authors: Pablo Martinez-Martin; John B Wetmore; Carmen Rodríguez-Blázquez; Tomoko Arakaki; Oscar Bernal; Victor Campos-Arillo; Christopher Cerda; Ingrid Estrada-Bellmann; Nélida Garretto; Letty Ginsburg; Jorge Uriel Máñez-Miró; Juan Carlos Martínez-Castrillo; Ivonne Pedroso; Marcos Serrano-Dueñas; Carlos Singer; Mayela Rodríguez-Violante; Francisco Vivancos Journal: Mov Disord Clin Pract Date: 2019-03-18
Authors: Panagiotis Bargiotas; Lukas Eugster; Michael Oberholzer; Ines Debove; M Lenard Lachenmayer; Johannes Mathis; Claudio Pollo; W M Michael Schüpbach; Claudio L Bassetti Journal: PLoS One Date: 2017-12-18 Impact factor: 3.240
Authors: Ekaterina Zhurakovskaya; Juuso Leikas; Tiina Pirttimäki; Francesc Casas Mon; Mikko Gynther; Rubin Aliev; Tomi Rantamäki; Heikki Tanila; Markus M Forsberg; Olli Gröhn; Jaakko Paasonen; Aaro J Jalkanen Journal: eNeuro Date: 2019-02-26
Authors: Martina Pfeffer; Zuzana Zimmermann; Suzana Gispert; Georg Auburger; Horst-Werner Korf; Charlotte von Gall Journal: Int J Mol Sci Date: 2018-06-03 Impact factor: 5.923