Literature DB >> 27798145

The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Ruzica Bago, Eeva Sommer, Pau Castel, Claire Crafter, Fiona P Bailey, Natalia Shpiro, José Baselga, Darren Cross, Patrick A Eyers, Dario R Alessi.   

Abstract

Entities:  

Year:  2016        PMID： 27798145      PMCID： PMC5069549          DOI： 10.15252/embj.201670010

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


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  1 in total

1.  PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Authors:  Pau Castel; Haley Ellis; Ruzica Bago; Eneda Toska; Pedram Razavi; F Javier Carmona; Srinivasaraghavan Kannan; Chandra S Verma; Maura Dickler; Sarat Chandarlapaty; Edi Brogi; Dario R Alessi; José Baselga; Maurizio Scaltriti
Journal:  Cancer Cell       Date:  2016-07-21       Impact factor: 31.743
  1 in total
  10 in total

1.  Reversible lysine-targeted probes reveal residence time-based kinase selectivity.

Authors:  Tangpo Yang; Adolfo Cuesta; Xiaobo Wan; Gregory B Craven; Brad Hirakawa; Penney Khamphavong; Jeffrey R May; John C Kath; John D Lapek; Sherry Niessen; Alma L Burlingame; Jordan D Carelli; Jack Taunton
Journal:  Nat Chem Biol       Date:  2022-05-19       Impact factor: 16.174

Review 2.  AKT/PKB Signaling: Navigating the Network.

Authors:  Brendan D Manning; Alex Toker
Journal:  Cell       Date:  2017-04-20       Impact factor: 41.582

3.  Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer.

Authors:  Hongtao Wang; Fang Huang; Zhe Zhang; Peng Wang; Yuan Luo; Hailiang Li; Na Li; Jian Wang; Jianguang Zhou; Yongan Wang; Shanhu Li
Journal:  Int J Biol Sci       Date:  2019-03-09       Impact factor: 6.580

Review 4.  Activation Mechanisms of the VPS34 Complexes.

Authors:  Yohei Ohashi
Journal:  Cells       Date:  2021-11-11       Impact factor: 7.666

5.  SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.

Authors:  Arturo Orlacchio; Michela Ranieri; Martina Brave; Valeria Antico Arciuch; Toni Forde; Daniela De Martino; Karen E Anderson; Phillip Hawkins; Antonio Di Cristofano
Journal:  Cancer Res       Date:  2017-10-20       Impact factor: 12.701

Review 6.  PI3K inhibitors are finally coming of age.

Authors:  Bart Vanhaesebroeck; Matthew W D Perry; Jennifer R Brown; Fabrice André; Klaus Okkenhaug
Journal:  Nat Rev Drug Discov       Date:  2021-06-14       Impact factor: 112.288

7.  Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer.

Authors:  Sitai Liang; Edward A Medina; Boajie Li; Samy L Habib
Journal:  Mol Oncol       Date:  2018-10-12       Impact factor: 6.603

8.  Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.

Authors:  Valentina Ranzuglia; Ilaria Lorenzon; Ilenia Pellarin; Maura Sonego; Alessandra Dall'Acqua; Sara D'Andrea; Sara Lovisa; Ilenia Segatto; Michela Coan; Jerry Polesel; Diego Serraino; Patrizia Sabatelli; Paola Spessotto; Barbara Belletti; Gustavo Baldassarre; Monica Schiappacassi
Journal:  Oncogene       Date:  2020-08-27       Impact factor: 9.867

Review 9.  Cataloguing the dead: breathing new life into pseudokinase research.

Authors:  Safal Shrestha; Dominic P Byrne; John A Harris; Natarajan Kannan; Patrick A Eyers
Journal:  FEBS J       Date:  2020-03-10       Impact factor: 5.542

10.  Serine/Threonine-Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase-3β/β-Catenin Pathway.

Authors:  Ya-Fei Li; Tian-Wen Wei; Yi Fan; Tian-Kai Shan; Jia-Teng Sun; Bing-Rui Chen; Zi-Mu Wang; Ling-Feng Gu; Tong-Tong Yang; Liu Liu; Chong Du; Yao Ma; Hao Wang; Rui Sun; Yong-Yue Wei; Feng Chen; Xue-Jiang Guo; Xiang-Qing Kong; Lian-Sheng Wang
Journal:  J Am Heart Assoc       Date:  2021-11-02       Impact factor: 5.501
  10 in total

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