| Literature DB >> 27797128 |
Chanyuan Jin1, Yunfei Zheng2, Yiping Huang2, Yunsong Liu1, Lingfei Jia3,4, Yongsheng Zhou1,5.
Abstract
Recently, long non-coding RNAs (lncRNAs) have emerged as critical players in gene regulation for multiple biological processes. However, their roles and functions in human adipose-derived stem cells (hASCs) differentiation remain unclear. In the present study, we investigated the role of lncRNA myocardial infarction-associated transcript (MIAT) in the osteogenic differentiation of hASCs. We found that the expression of MIAT was downregulated in a time-dependent manner during hASCs osteoinduction. MIAT knockdown promoted osteogenic differentiation of hASCs both in vitro and in vivo. Moreover, MIAT expression was increased upon tumor necrosis factor-α treatment and MIAT knockdown reversed the negative effects of inflammation on osteoblastic differentiation. This study improves our knowledge of lncRNAs in governing the osteogenic differentiation of hASCs and may provide novel therapeutic strategies for treating bone diseases.Entities:
Keywords: human adipose-derived stem cells; inflammation; lncRNA MIAT; osteoblastic
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Year: 2016 PMID： 27797128 DOI： 10.1002/cbin.10697
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612