Gianluca Campo1,2, Rita Pavasini3, Elisa Maietti4, Elisabetta Tonet3, Paolo Cimaglia3, Giulia Scillitani3, Giulia Bugani3, Matteo Serenelli3, Fatima Zaraket3, Cristina Balla3, Filippo Trevisan3, Simone Biscaglia3, Biagio Sassone5, Marcello Galvani6, Roberto Ferrari3,7,8, Stefano Volpato4. 1. Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy. cmpglc@unife.it. 2. Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Center, Ferrara, Italy. cmpglc@unife.it. 3. Cardiology Unit, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Via Aldo Moro, 8, 44124, Cona, FE, Italy. 4. Department of Medical Science, University of Ferrara, Ferrara, Italy. 5. Division of Cardiology, Cento Hospital, Ferrara, Italy. 6. Unità Operativa di Cardiologia, Ospedale GB Morgagni, Forlì, Italy. 7. Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Center, Ferrara, Italy. 8. Maria Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy.
Abstract
BACKGROUND: Frailty has become a high-priority issue in cardiovascular medicine because of the aging of cardiovascular patients. Simple and reproducible tools to assess frailty in elderly patients are clearly on demand. Their application may help physicians in the selection of invasive and medical treatments and in the timing and modality of the follow-up. The frailty in elderly patients receiving cardiac interventional procedures (FRASER) program is designed with the aim to validate the use of the short physical performance battery (SPPB) as prognostic tools in patients admitted to hospital for acute coronary syndrome (ACS). METHODS: The FRASER program is a multicenter prospective study involving 4 Italian cardiology units. The FRASER program enrolls only patients aged ≥70 years. The core of the FRASER program includes patients admitted to hospital for ACS. The aims are (1) to describe SPPB distribution before hospital discharge and (2) to investigate the prognostic role of SPPB score. The primary outcome is a composite of 1-year all-cause mortality and hospital readmission for any cause. Ancillary analyses will be focused on different study populations (patients hospitalized for arrhythmias or acute heart failure or symptomatic severe aortic stenosis) and on different tools to assess frailty (multidimensional prognostic index, clinical frailty score, grip strength). DISCUSSION: The FRASER program will fill critical gaps in the knowledge regarding the link between frailty, cardiovascular disease, interventional procedures and outcome and will help physicians in the generation of a more personalized risk assessment and in the identification of potential targets for interventions.
BACKGROUND: Frailty has become a high-priority issue in cardiovascular medicine because of the aging of cardiovascular patients. Simple and reproducible tools to assess frailty in elderly patients are clearly on demand. Their application may help physicians in the selection of invasive and medical treatments and in the timing and modality of the follow-up. The frailty in elderly patients receiving cardiac interventional procedures (FRASER) program is designed with the aim to validate the use of the short physical performance battery (SPPB) as prognostic tools in patients admitted to hospital for acute coronary syndrome (ACS). METHODS: The FRASER program is a multicenter prospective study involving 4 Italian cardiology units. The FRASER program enrolls only patients aged ≥70 years. The core of the FRASER program includes patients admitted to hospital for ACS. The aims are (1) to describe SPPB distribution before hospital discharge and (2) to investigate the prognostic role of SPPB score. The primary outcome is a composite of 1-year all-cause mortality and hospital readmission for any cause. Ancillary analyses will be focused on different study populations (patients hospitalized for arrhythmias or acute heart failure or symptomatic severe aortic stenosis) and on different tools to assess frailty (multidimensional prognostic index, clinical frailty score, grip strength). DISCUSSION: The FRASER program will fill critical gaps in the knowledge regarding the link between frailty, cardiovascular disease, interventional procedures and outcome and will help physicians in the generation of a more personalized risk assessment and in the identification of potential targets for interventions.
Authors: Elisabetta Tonet; Albert Ariza-Solé; Matteo Serenelli; Francesc Formiga; Juan Sanchis; Rita Pavasini; Pablo Diez-Villanueva; Francesco Vitali; Clara Bonanad; Giovanni Grazzi; Antoni Carol; Giorgio Chiaranda; Graziella Pompei; Laura Sofia Cardelli; Serena Caglioni; Federico Gibiino; Stefano Volpato; Gianluca Campo Journal: BMC Med Date: 2022-01-20 Impact factor: 8.775