Literature DB >> 27796602

Conservative and surgical treatment of pediatric asymptomatic lumbosacral lipoma: a meta-analysis.

Yang Xiong1, Liu Yang1, Wang Zhen1, Dong Fangyong1, Wan Feng2, Lei Ting1.   

Abstract

The aim of this study is to compare the outcomes of surgical and conservative treatments of pediatric asymptomatic lumbosacral lipomas, and to address whether the patients can benefit from prophylactic surgeries. The literature reports of surgical and conservative treatments of child asymptomatic lumbosacral lipomas were reviewed and collected, and a meta-analysis of the reports regarding the incidence of sphincter and lower limb dysfunctions was performed. A total of five literatures were collected, containing a total of 403 patients, among which 124 patients received conservative treatments with 32 (25.81%) cases developing neurological dysfunctions during follow-up, and 279 received prophylactic surgical treatments with 30 (10.75%) patients developing neurological dysfunctions in follow-up, the difference being statistically significant (P ≤ 0.05). For pediatric asymptomatic lumbosacral lipomas of the three major subtypes, the limited source of literature so far suggests that prophylactic surgery is superior to conservative strategy in preventing the patients from neurological deterioration. Larger patient cohorts, randomized studies, and longer length of follow-ups are needed for further corroboration.

Entities:  

Keywords:  Asymptomatic, lumbosacral lipoma; Conservative and surgical treatment; Neurologic dysfunction; Pediatric

Mesh:

Year:  2016        PMID: 27796602     DOI: 10.1007/s10143-016-0796-6

Source DB:  PubMed          Journal:  Neurosurg Rev        ISSN: 0344-5607            Impact factor:   3.042


  20 in total

Review 1.  Congenital lumbosacral lipomas.

Authors:  A Pierre-Kahn; M Zerah; D Renier; G Cinalli; C Sainte-Rose; A Lellouch-Tubiana; F Brunelle; M Le Merrer; Y Giudicelli; J Pichon; B Kleinknecht; F Nataf
Journal:  Childs Nerv Syst       Date:  1997-06       Impact factor: 1.475

2.  Long-term benefits of early neurosurgery for lipomyelomeningocele.

Authors:  H Y Wu; B A Kogan; L S Baskin; M S Edwards
Journal:  J Urol       Date:  1998-08       Impact factor: 7.450

3.  The natural history and management of patients with congenital deficits associated with lumbosacral lipomas.

Authors:  Albert Tu; Ross Hengel; D Douglas Cochrane
Journal:  Childs Nerv Syst       Date:  2016-01-11       Impact factor: 1.475

4.  Late effects of early surgery on lipoma and lipomeningocele in children less than 1 year old.

Authors:  N Satar; S B Bauer; R M Scott; J Shefner; M Kelly; M Darbey
Journal:  J Urol       Date:  1997-04       Impact factor: 7.450

5.  Congenital lumbosacral lipomas: pitfalls in analysing the results of prophylactic surgery.

Authors:  Neil L Dorward; James H Scatliff; Richard D Hayward
Journal:  Childs Nerv Syst       Date:  2002-07-09       Impact factor: 1.475

6.  Effect of surgical repair on the neurologic function in infants with lipomeningocele.

Authors:  S Sathi; J R Madsen; S Bauer; R M Scott
Journal:  Pediatr Neurosurg       Date:  1993 Sep-Oct       Impact factor: 1.162

7.  Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan.

Authors:  Shizuo Oi; Sadahiro Nomura; Masato Nagasaka; Hajime Arai; Reizo Shirane; Yasuo Yamanouchi; Hiroshi Nishimoto; Hiroaki Date
Journal:  J Neurosurg Pediatr       Date:  2009-05       Impact factor: 2.375

Review 8.  Spinal lipomas: clinical spectrum, embryology, and treatment.

Authors:  Michael A Finn; Marion L Walker
Journal:  Neurosurg Focus       Date:  2007       Impact factor: 4.047

9.  Asymptomatic lipomas of the medullary conus: surgical treatment versus conservative management.

Authors:  Giuseppe Talamonti; Giuseppe D'Aliberti; Michele Nichelatti; Alberto Debernardi; Marco Picano; Tiziana Redaelli
Journal:  J Neurosurg Pediatr       Date:  2014-06-27       Impact factor: 2.375

10.  Asymptomatic lumbosacral lipomas--a natural history study.

Authors:  Victoria Wykes; Divyesh Desai; Dominic N P Thompson
Journal:  Childs Nerv Syst       Date:  2012-05-05       Impact factor: 1.475

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