Literature DB >> 27796442

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.

Bixuan Lin1, Ashley E Ciecko1, Erin MacKinney1,2, David V Serreze3, Yi-Guang Chen4.   

Abstract

Type 1 diabetes (T1D) results from complex interactions between genetic and environmental factors. The nonobese diabetic (NOD) mouse develops spontaneous T1D and has been used extensively to study the genetic control of this disease. T1D is suppressed in NOD mice congenic for the C57BL/10 (B10)-derived Idd9 resistance region on chromosome 4. Previous studies conducted by other investigators have identified four subregions (Idd9.1, Idd9.2, Idd9.3, and Idd9.4) where B10-derived genes suppress T1D development in NOD mice. We independently generated and characterized six congenic strains containing B10-derived intervals that partially overlap with the Idd9.1 and Idd9.4 regions. T1D incidence studies have revealed a new B10-derived resistance region proximal to Idd9.1. Our results also indicated that a B10-derived gene(s) within the Idd9.4 region suppressed the diabetogenic activity of CD4 T cells and promoted CD103 expression on regulatory T cells indicative of an activated phenotype. In addition, we suggest the presence of a B10-derived susceptibility gene(s) in the Idd9.1/Idd9.4 region. These results provide additional information to improve our understanding of the complex genetic control by the Idd9 region.

Entities:  

Keywords:  Idd9; NOD mouse; Regulatory T cells; Type 1 diabetes

Mesh：

Substances：

Year:  2016        PMID： 27796442      PMCID： PMC5335865          DOI： 10.1007/s00251-016-0957-3

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  39 in total

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2.  Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Review 3.  Type 1 diabetes genes and pathways shared by humans and NOD mice.

Authors:  Linda S Wicker; Jan Clark; Heather I Fraser; Valerie E S Garner; Andrea Gonzalez-Munoz; Barry Healy; Sarah Howlett; Kara Hunter; Dan Rainbow; Raymond L Rosa; Luc J Smink; John A Todd; Laurence B Peterson
Journal:  J Autoimmun       Date:  2005-10-28       Impact factor: 7.094

4.  A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.

Authors:  Randal K Gregg; Renu Jain; Scott J Schoenleber; Rohit Divekar; J Jeremiah Bell; Hyun-Hee Lee; Ping Yu; Habib Zaghouani
Journal:  J Immunol       Date:  2004-12-15       Impact factor: 5.422

5.  Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.

Authors:  Emma E Hamilton-Williams; S B Justin Wong; Xavier Martinez; Daniel B Rainbow; Kara M Hunter; Linda S Wicker; Linda A Sherman
Journal:  Diabetes       Date:  2010-03-18       Impact factor: 9.461

6.  Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.

Authors:  Shannon M Pop; Carmen P Wong; Donna A Culton; Stephen H Clarke; Roland Tisch
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7.  Molecular signatures differentiate immune states in type 1 diabetic families.

Authors:  Yi-Guang Chen; Susanne M Cabrera; Shuang Jia; Mary L Kaldunski; Joanna Kramer; Sami Cheong; Rhonda Geoffrey; Mark F Roethle; Jeffrey E Woodliff; Carla J Greenbaum; Xujing Wang; Martin J Hessner
Journal:  Diabetes       Date:  2014-04-23       Impact factor: 9.461

8.  Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.

Authors:  S Alice Long; Karen Cerosaletti; Paul L Bollyky; Megan Tatum; Heather Shilling; Sheng Zhang; Zhong-Yin Zhang; Catherine Pihoker; Srinath Sanda; Carla Greenbaum; Jane H Buckner
Journal:  Diabetes       Date:  2009-10-29       Impact factor: 9.461

9.  Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.

Authors:  Jochen Huehn; Kerstin Siegmund; Joachim C U Lehmann; Christiane Siewert; Uta Haubold; Markus Feuerer; Gudrun F Debes; Joerg Lauber; Oliver Frey; Grzegorz K Przybylski; Uwe Niesner; Maurus de la Rosa; Christian A Schmidt; Rolf Bräuer; Jan Buer; Alexander Scheffold; Alf Hamann
Journal:  J Exp Med       Date:  2004-02-02       Impact factor: 14.307

10.  Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.

Authors:  Emma E Hamilton-Williams; Daniel B Rainbow; Jocelyn Cheung; Mikkel Christensen; Paul A Lyons; Laurence B Peterson; Charles A Steward; Linda A Sherman; Linda S Wicker
Journal:  Mamm Genome       Date:  2013-08-11       Impact factor: 2.957
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  1 in total

1.  The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.

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Journal:  Front Endocrinol (Lausanne)       Date:  2018-02-23       Impact factor: 5.555
  1 in total

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