| Literature DB >> 27795883 |
Hinali Zaveri1, Amit Surve1, Daniel Cottam1, Christina Summerhays1, Austin Cottam1, Christina Richards1, LeGrand Belnap1, Walter Medlin1.
Abstract
BACKGROUND: There is a scarcity of data available to determine the safety and effectiveness of bariatric surgery in the elderly population. Additionally, there are no studies showing the effect of the single anastomosis duodenal switch (SADS) has on the elderly obese, in comparison with other more popular procedures. Here we compare laparoscopic gastric band surgery (LAGB), Laparoscopic Roux-en-Y gastric bypass surgery (LRYGB), and the SADS to analyze the weight loss, perioperative and postoperative morbidity in the patients >70 years of age at a single US center.Entities:
Keywords: Duodenal switch; Elderly; LAGB; RYGB; Weight loss
Year: 2016 PMID: 27795883 PMCID: PMC5055526 DOI: 10.1186/s40064-016-3392-x
Source DB: PubMed Journal: Springerplus ISSN: 2193-1801
Patients baseline demographic data
| LAGB | LRYGB | SADS | p value | |
|---|---|---|---|---|
| N | 24 | 14 | 15 | |
| Male/female | 6/18 | 5/9 | 7/8 | .38 |
| Agea | 71.9 ± 2 | 73.1 ± 2.5 | 73.6 ± 2.9 | .08 |
| Weighta | 265.5 ± 35 | 253.2 ± 50.2 | 273.8 ± 36.3 | .46 |
| BMIa | 44.3 ± 5.9 | 40.8 ± 5.2 | 44.2 ± 5.4 | .17 |
|
| ||||
| Sleep apnea | 10/24 (42 %) | 10/14 (71 %) | 11/15 (73 %) | .08 |
| Diabetes | 12/24 (50 %) | 6/14 (42 %) | 7/15 (47 %) | .97 |
| GERD | 6/24 (25 %) | 6/14 (43 %) | 8/15 (53 %) | .19 |
| Hypertension | 19/24 (79 %) | 12/14 (86 %) | 11/15 (73 %) | .71 |
LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch, GERD gastroesophageal reflux disease
aValues are expressed as mean ± standard deviation
Complications seen with all the three procedures
| LAGB | LRYGB | SADS |
|---|---|---|
| Early | Early | Early |
| Pneumonia-1 | Pneumonia-1 | Acute cholecystitis, sub hepatic abcess-1i |
| Reflux-1 | Wound infection-1 | Wound infection-1 |
| Stricture-1e | Gastro cutaneous fistula-1j | |
| Leak and abcess-1f | ||
| Total early complication rate-8.3 % | Total early complication rate-28.5 % | Total early complication rate-20 % |
| Late | Late | Late |
| Nausea and vomiting-5a | Stricture-1g | Diarrhea-2k |
| Reflux-3b | Reflux-2h | Stricture needing dilation-1 |
| Weight regain-4 | Chronic diarrhea-1 | |
| Slipped lap band-2c | ||
| Erosion of lap band port-1d | ||
| Total late complication rate-62.5 % | Total late complication rate-28.5 % | Total late complication rate-20 % |
LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch
In LAGB group
aAll the 5 patient had nausea and vomiting because of band being too tight. All of them got their band adjusted
bOne of the patient had severe reflux, couldn’t keep any food down and, needed a larger band replacement
cOne of the patient with slipped band had inverted port 2 years later and needed the band removal
dPatient with the erosion of lap band port needed the surgery for the exchange of lap band port for low profile port
In LRYGB group
eOne patient complained of GERD and underwent EGD. EGD showed stricture at the gastric outlet obstruction requiring dilation
fThis patient had history of multiple abdominal surgeries who underwent elective LRYGB, left inguinal hernia repair and hiatal hernia repair. Intraoperatively, patient had bladder perforation requiring bladder reconstruction. On post-operative day 1, patient developed intra-abdominal leak with bile noted on JP drain. Patient was taken back to the operating room and underwent exploratory laparotomy with incision and drainage, removal of abdominal mesh, and partial omentectomy due to marginally vascularized omentum. Patient was transferred to intensive care unit (ICU) and was extubated. On post-operative day 10, patient developed sepsis and abdominal abscess. Patient was treated with antibiotics and was placed on total parental nutrition (TPN) because of severe malnutrition. At last, patient developed acute renal insufficiency secondary to pre-renal azotemia. Patient got discharged after 17 days and was transferred to rehab for recovery
gThis patient complained of progressive dysphagia, who also underwent EGD which showed Gastrojejunal (GJ) stricture needing dilation. This patient after 1 year developed ulcers and fistula and underwent revision of GJ anastomosis
hOne of the 2 patients who complained of reflux also had severe abdominal pain. EGD showed hiatal hernia and bifid gastric pouch. Patient underwent hiatal hernia repair with mesh and partial gastrectomy
In SADS group
iThis patient had acute cholecystitis and sub hepatic abscess needing re-admission within 30 days of discharge. The patient underwent cholecystectomy and drainage of abscess
jThis is the second patient who needed re-admission within 30 days of discharge for the treatment of gastro cutaneous fistula
kOne of the patients had chronic diarrhea, excessive weight loss, and hypoalbuminemia requiring common channel lengthening approximately 1 year after SADS
Percentage excess BMI lost at 3, 6, 9, 12, 15, and 18 months for the LAGB, LRYGB and SADS
| %EBMIL | 3 months | 6 months | 9 months | 12 months | 15 months | 18 months |
|---|---|---|---|---|---|---|
| LAGB | 25.6 | 32.4 | 35.3 | 36.6 | 37 | 37.2 |
| CI | (22.1, 29.1) | (29.4, 35.5) | (32.7, 38) | (33.3, 39.8) | (33.2, 40.8) | (33.1, 41.4) |
| N | 23/24 (95.8 %) | 22/24 (91.7 %) | 21/24 (87.5 %) | 21/24 (87.5 %) | 21/24 (87.5 %) | 20/24 (83.3 %) |
| LRYGB | 41 | 60.2 | 72.5 | 80.6 | 85.2 | 88.4 |
| CI | (37.8, 45.5) | (55.3, 65.2) | (68, 77) | (76.5, 84.8) | (80.2, 90.1) | (82.1, 94.7) |
| N | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 11/14 (78.6 %) |
| SADS | 49.1 | 63.4 | 75.2 | 85.5 | 94.1 | 100.6 |
| CI | (41.8, 56.5) | (57.6, 69.2) | (69.8, 80.7) | (79.6, 91.4) | (88, 100.2) | (94, 107.3) |
| N | 14/15 (93.3 %) | 12/15 (80 %) | 10/15 (66.7 %) | 9/11 (81.8 %) | 7/10 (70 %) | 7/8 (87.5 %) |
| p value | >.05 | >.05 | <.05 | <.05 | >.05 | <.05 |
LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch, %EBMIL percentage excess BMI point lost, CI confidence interval, N number of patients/percentage follow-ups available
Fig. 1BMI points lost between three procedures during 18 months. LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch
Percentage excess weight loss (%EWL) at 3, 6, 9, 12, 15, and 18 months, for the LAGB, LRYGB, and the SADS
| %EWL | 3 months | 6 months | 9 months | 12 months | 15 months | 18 months |
|---|---|---|---|---|---|---|
| LAGB | 22.5 | 28.4 | 29.9 | 30.3 | 30.4 | 30.4 |
| CI | (19.3, 25.7) | (26.2, 30.5) | (27.4, 32.3) | (27.5, 33) | (27.5, 33.2) | (27.5, 33.3) |
| N | 23/24 (95.8 %) | 22/24 (91.7 %) | 21/24 (87.5 %) | 21/24 (87.5 %) | 21/24 (87.5 %) | 20/24 (83.3 %) |
| LRYGB | 35.2 | 53.5 | 63.6 | 69.1 | 71.7 | 73.2 |
| CI | (31.5, 38.9) | (49.9, 57.1) | (60.3, 66.9) | (65.3, 72.9) | (67.2, 76.1) | (68, 78.3) |
| N | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 12/14 (85.7 %) | 11/14 (78.6 %) |
| SADS | 40.4 | 50.6 | 59.3 | 67.4 | 74.2 | 80.3 |
| CI | (34.5, 46.3) | (45.7, 55.5) | (55, 63.7) | (62.6, 72.2) | (69.1, 79.4) | (74.7, 86.2) |
| N | 14/15 (93.3 %) | 12/15 (80 %) | 10/15 (66.7 %) | 9/11 (81.8 %) | 7/10 (70 %) | 7/8 (87.5 %) |
| p value | >.05 | >.05 | >.05 | >.05 | >.05 | >.05 |
LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch, %EWL percentage excess weight loss, CI confidence interval, N number of patients/percentage follow-ups available at each time point
Resolution of comorbidities
| LAGB (n = 24) | LRYGB (n = 14) | SADS (n = 15) | p value | |
|---|---|---|---|---|
| Sleep apnea | 5/10 (50 %) | 6/10 (60 %) | 5/10 (50 %) | .96 |
| Diabetes | 8/12 (66.7 %) | 5/6 (83.3 %) | 7/7 (100 %) | .84 |
| GERD | 3/6 (50 %) | 3/6 (50 %) | 4/7 (57.1 %) | .98 |
| Hypertension | 15/19 (78.9 %) | 6/12 (50 %) | 10/11 (90.9 %) | .64 |
LAGB laparoscopic gastric banding, LRYGB laparoscopic Roux-en-Y gastric bypass, SADS single anastomosis duodenal switch, GERD gastroesophageal reflux disease