Literature DB >> 2779579

The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites.

T Deng1, Y Li, K Jolliff, L F Johnson.   

Abstract

The promoter region of the mouse thymidylate synthase gene was analyzed by deletion and site-directed mutagenesis. Elimination of an upstream Sp1 element reduced expression threefold, whereas elimination of an adenovirus upstream stimulatory factor element had little effect. All of the upstream elements that are essential for promoter activity are located within 22 nucleotides of the first transcriptional initiation site.

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Year:  1989        PMID： 2779579      PMCID： PMC362476          DOI： 10.1128/mcb.9.9.4079-4082.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  26 in total

1.  Construction and expression of mouse thymidylate synthase minigenes.

Authors:  J W DeWille; C H Jenh; T Deng; C J Harendza; L F Johnson
Journal:  J Biol Chem       Date:  1988-01-05       Impact factor: 5.157

2.  Structure of the gene for mouse thymidylate synthase. Locations of introns and multiple transcriptional start sites.

Authors:  T L Deng; D W Li; C H Jenh; L F Johnson
Journal:  J Biol Chem       Date:  1986-12-05       Impact factor: 5.157

3.  The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter.

Authors:  L A Chodosh; R W Carthew; J G Morgan; G R Crabtree; P A Sharp
Journal:  Science       Date:  1987-10-30       Impact factor: 47.728

4.  Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.

Authors:  W S Dynan; R Tjian
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

5.  Control of thymidylate synthase mRNA content and gene transcription in an overproducing mouse cell line.

Authors:  C H Jenh; P K Geyer; L F Johnson
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

6.  An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.

Authors:  R W Carthew; L A Chodosh; P A Sharp
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

7.  Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.

Authors:  M Sawadogo; R G Roeder
Journal:  Cell       Date:  1985-11       Impact factor: 41.582

8.  Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression.

Authors:  R L Nussbaum; R M Walmsley; J G Lesko; S D Airhart; D H Ledbetter
Journal:  Am J Hum Genet       Date:  1985-11       Impact factor: 11.025

9.  A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Authors:  R M Dale; B A McClure; J P Houchins
Journal:  Plasmid       Date:  1985-01       Impact factor: 3.466

10.  Cell cycle-dependent expression of thymidylate synthase in Saccharomyces cerevisiae.

Authors:  R K Storms; R W Ord; M T Greenwood; B Mirdamadi; F K Chu; M Belfort
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272
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  11 in total

1.  The mouse Pgk-1 gene promoter contains an upstream activator sequence.

Authors:  M W McBurney; L C Sutherland; C N Adra; B Leclair; M A Rudnicki; K Jardine
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

2.  Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter.

Authors:  Y Geng; L F Johnson
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

3.  Cloning, chromosomal location, and characterization of mouse E2F1.

Authors:  Y Li; J E Slansky; D J Myers; N R Drinkwater; W G Kaelin; P J Farnham
Journal:  Mol Cell Biol       Date:  1994-03       Impact factor: 4.272

4.  Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication.

Authors:  G Gribaudo; L Riera; D Lembo; M De Andrea; M Gariglio; T L Rudge; L F Johnson; S Landolfo
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

5.  Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression.

Authors:  C M Powell; T L Rudge; Q Zhu; L F Johnson; U Hansen
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

6.  Multiple protein-DNA interactions in the TATAA-less mouse thymidylate synthase promoter.

Authors:  K Jolliff; Y Li; L F Johnson
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

7.  Stimulation of gene expression by introns: conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence.

Authors:  M Korb; Y Ke; L F Johnson
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

8.  Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.

Authors:  J Ash; Y Ke; M Korb; L F Johnson
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Regulation of mouse thymidylate synthase gene expression in growth-stimulated cells: upstream S phase control elements are indistinguishable from the essential promoter elements.

Authors:  J Ash; W C Liao; Y Ke; L F Johnson
Journal:  Nucleic Acids Res       Date:  1995-11-25       Impact factor: 16.971

10.  Bidirectional promoter of the mouse thymidylate synthase gene.

Authors:  W C Liao; J Ash; L F Johnson
Journal:  Nucleic Acids Res       Date:  1994-10-11       Impact factor: 16.971
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