Literature DB >> 27795371

In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species.

Hamed Fakhim1,2, Saeed Emami3, Afsane Vaezi1,2, Seyedeh Mahdieh Hashemi3, Leila Faeli1,2, Kambiz Diba4, Eric Dannaoui5, Hamid Badali6,7.   

Abstract

The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  Candida species; In vitro susceptibility; triazole derivatives

Mesh：

Substances：

Year:  2016        PMID： 27795371      PMCID： PMC5192144          DOI： 10.1128/AAC.01106-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009).

Authors:  Michael A Pfaller; Shawn A Messer; Gary J Moet; Ronald N Jones; Mariana Castanheira
Journal:  Int J Antimicrob Agents       Date:  2011-04-22       Impact factor: 5.283

Review 2.  Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012.

Authors:  M A Pfaller; D J Diekema
Journal:  J Clin Microbiol       Date:  2012-06-27       Impact factor: 5.948

Review 3.  Management of invasive fungal infections: a role for polyenes.

Authors:  Pranatharthi Chandrasekar
Journal:  J Antimicrob Chemother       Date:  2010-12-14       Impact factor: 5.790

4.  Anti-Candida Activity of New Azole Derivatives Alone and in Combination with Fluconazole.

Authors:  Ce Shi; Chunli Liu; Jinyan Liu; Ying Wang; Jian Li; Mingjie Xiang
Journal:  Mycopathologia       Date:  2015-05-15       Impact factor: 2.574

5.  ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.

Authors:  O A Cornely; M Bassetti; T Calandra; J Garbino; B J Kullberg; O Lortholary; W Meersseman; M Akova; M C Arendrup; S Arikan-Akdagli; J Bille; E Castagnola; M Cuenca-Estrella; J P Donnelly; A H Groll; R Herbrecht; W W Hope; H E Jensen; C Lass-Flörl; G Petrikkos; M D Richardson; E Roilides; P E Verweij; C Viscoli; A J Ullmann
Journal:  Clin Microbiol Infect       Date:  2012-12       Impact factor: 8.067

6.  Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives.

Authors:  Dan Ji; JunRui Lu; BoWei Lu; ChunWei Xin; JiangBei Mu; JianFa Li; ChunYong Peng; XiuRong Bao
Journal:  Bioorg Med Chem Lett       Date:  2013-02-14       Impact factor: 2.823

7.  Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents.

Authors:  Seyedeh Mahdieh Hashemi; Hamid Badali; Hamid Irannejad; Mohammad Shokrzadeh; Saeed Emami
Journal:  Bioorg Med Chem       Date:  2015-02-16       Impact factor: 3.641

8.  Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity.

Authors:  Seyedeh Mahdieh Hashemi; Hamid Badali; Mohammad Ali Faramarzi; Nasrin Samadi; Mohammad Hosein Afsarian; Hamid Irannejad; Saeed Emami
Journal:  Mol Divers       Date:  2014-09-03       Impact factor: 2.943

9.  Invasive candidiasis in intensive care units in China: a multicentre prospective observational study.

Authors:  Fengmei Guo; Yi Yang; Yan Kang; Bin Zang; Wei Cui; Bingyu Qin; Yingzhi Qin; Qiang Fang; Tiehe Qin; Dongpo Jiang; Weiqin Li; Qin Gu; Hongsheng Zhao; Dawei Liu; Xiangdong Guan; Jianguo Li; Xiaochun Ma; Kaijiang Yu; Dechang Chan; Jing Yan; Yaoqing Tang; Wei Liu; Ruoyu Li; Haibo Qiu
Journal:  J Antimicrob Chemother       Date:  2013-03-29       Impact factor: 5.790

Review 10.  Pharmacokinetics and tissue penetration of fluconazole in humans.

Authors:  K W Brammer; P R Farrow; J K Faulkner
Journal:  Rev Infect Dis       Date:  1990 Mar-Apr
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  8 in total

1.  In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris.

Authors:  Hamed Fakhim; Anuradha Chowdhary; Anupam Prakash; Afsane Vaezi; Eric Dannaoui; Jacques F Meis; Hamid Badali
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

2.  Evaluation of a new matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system for the identification of yeast isolation.

Authors:  Hyeyoung Lee; Ji-Hyun Park; Junsang Oh; Sungil Cho; Jehyun Koo; Ik Chun Park; Jiwoo Kim; Sehyun Park; Ji Seon Choi; So Youn Shin; Gi-Ho Sung; Jayoung Kim
Journal:  J Clin Lab Anal       Date:  2018-10-08       Impact factor: 2.352

3.  Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry.

Authors:  Narges Aslani; Ghasem Janbabaei; Mahdi Abastabar; Jacques F Meis; Mahasti Babaeian; Sadegh Khodavaisy; Teun Boekhout; Hamid Badali
Journal:  BMC Infect Dis       Date:  2018-01-08       Impact factor: 3.090

4.  Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran.

Authors:  Rasoul Mohammadi; Hossein Mirhendi; Mohammad Taghi Hedayati; Hamid Badali
Journal:  Iran J Public Health       Date:  2017-02       Impact factor: 1.429

5.  Antifungal Susceptibility of Candida Species Isolated from Horticulturists with Onychomycosis in Piauí, Brazil.

Authors:  Mitra Mobin; Maria Walderez Szeszs; Juliana Possatto Takahashi; Marilena Martins; Daise Damaris Carnietto de Hippólito; Jhonatas Cley Santos Porto; João Batista Teles; Sidney Gonçalo de Lima; Marcia de Souza Carvalho Melhem
Journal:  Iran J Public Health       Date:  2018-12       Impact factor: 1.429

6.  Isolation, characterization, and molecular identification of Candida species from urinary tract infections.

Authors:  Amin Gharanfoli; Elaheh Mahmoudi; Roya Torabizadeh; Farzad Katiraee; Saeid Faraji
Journal:  Curr Med Mycol       Date:  2019-06

7.  Two New 1,3,4-Oxadiazoles With Effective Antifungal Activity Against Candida albicans.

Authors:  Isis Regina Grenier Capoci; Karina Mayumi Sakita; Daniella Renata Faria; Franciele Abigail Vilugron Rodrigues-Vendramini; Glaucia Sayuri Arita; Admilton Gonçalves de Oliveira; Maria Sueli Felipe; Bernard Maigret; Patricia de Souza Bonfim-Mendonça; Erika Seki Kioshima; Terezinha Inez Estivalet Svidzinski
Journal:  Front Microbiol       Date:  2019-09-12       Impact factor: 5.640

Review 8.  Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox.

Authors:  Aidan Kane; Dee A Carter
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-14
  8 in total

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