Alireza Khodabande1, Mohammad Reza Niyousha2, Ramak Roohipoor1. 1. Fabrabi Eye Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 2. Fabrabi Eye Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: mreza63neusha@gmail.com.
Abstract
PURPOSE: To determine whether a low dose (0.25 mg/0.01 mL) of intravitreal bevacizumab is effective in the treatment of type 1 retinopathy of prematurity (ROP). METHODS: This prospective, noncomparative, interventional case series included all consecutive infants who received 0.25 mg/0.01 mL of intravitreal bevacizumab for type 1 ROP. Infants were followed for ROP persistence/recurrence until 90 weeks' postmenstrual age. RESULTS: A total of 49 eyes of 25 infants (24 bilateral and 1 unilateral) underwent intravitreal injection of a reduced dose (0.25 mg/0.01 mL) of intravitreal bevacizumab. ROP regressed in all eyes. Follow-up continued until 90 weeks' postmenstrual age and showed no recurrences of plus disease or neovascularization. CONCLUSIONS: All eyes treated with 0.25mg/0.01ml intravitreal bevacizumab showed complete regression, with no recurrence of plus disease or neovascularization. No safety issues were attributable to bevacizumab during the study period. Copyright Â
PURPOSE: To determine whether a low dose (0.25 mg/0.01 mL) of intravitreal bevacizumab is effective in the treatment of type 1 retinopathy of prematurity (ROP). METHODS: This prospective, noncomparative, interventional case series included all consecutive infants who received 0.25 mg/0.01 mL of intravitreal bevacizumab for type 1 ROP. Infants were followed for ROP persistence/recurrence until 90 weeks' postmenstrual age. RESULTS: A total of 49 eyes of 25 infants (24 bilateral and 1 unilateral) underwent intravitreal injection of a reduced dose (0.25 mg/0.01 mL) of intravitreal bevacizumab. ROP regressed in all eyes. Follow-up continued until 90 weeks' postmenstrual age and showed no recurrences of plus disease or neovascularization. CONCLUSIONS: All eyes treated with 0.25mg/0.01ml intravitreal bevacizumab showed complete regression, with no recurrence of plus disease or neovascularization. No safety issues were attributable to bevacizumab during the study period. Copyright Â
Authors: Sharon F Freedman; Amra Hercinovic; David K Wallace; Raymond T Kraker; Zhuokai Li; Amit R Bhatt; Charline S Boente; Eric R Crouch; G Baker Hubbard; David L Rogers; Deborah VanderVeen; Michael B Yang; Nathan L Cheung; Susan A Cotter; Jonathan M Holmes Journal: Ophthalmology Date: 2022-06-01 Impact factor: 14.277
Authors: David K Wallace; Raymond T Kraker; Sharon F Freedman; Eric R Crouch; Amit R Bhatt; M Elizabeth Hartnett; Michael B Yang; David L Rogers; Amy K Hutchinson; Deborah K VanderVeen; Kathryn M Haider; R Michael Siatkowski; Trevano W Dean; Roy W Beck; Michael X Repka; Lois E Smith; William V Good; Lingkun Kong; Susan A Cotter; Jonathan M Holmes Journal: JAMA Ophthalmol Date: 2020-06-01 Impact factor: 7.389