Karolina Förnvik1, Shaian Zolfaghari2, Leif G Salford2, Henrietta Nittby Redebrandt2. 1. The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden karolina.fornvik@med.lu.se. 2. The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Abstract
BACKGROUND: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. MATERIALS AND METHODS: A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated. RESULTS: No prolonged survival was seen in animals treated with ITPP. The route of ITPP administration did not affect outcome. CONCLUSION: ITPP had no favourable effect upon survival in our animal model with RG2 glioblastoma tumours in Fischer 344 rats. Copyright
BACKGROUND:Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. MATERIALS AND METHODS: A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated. RESULTS: No prolonged survival was seen in animals treated with ITPP. The route of ITPP administration did not affect outcome. CONCLUSION:ITPP had no favourable effect upon survival in our animal model with RG2 glioblastoma tumours in Fischer 344 rats. Copyright
Authors: Thanh-Trang Cao-Pham; An Tran-Ly-Binh; Arne Heyerick; Catherine Fillée; Nicolas Joudiou; Bernard Gallez; Bénédicte F Jordan Journal: NMR Biomed Date: 2019-11-25 Impact factor: 4.044