Literature DB >> 27793887

Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype.

Leonard Amaral1,2, Gabriella Spengler3, Joseph Molnar3.   

Abstract

The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line. Copyright
© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Entities:  

Keywords:  Non-toxic compounds isolated from natural sources (plants); induction of apoptosis; inhibition of P-glycoprotein (ABCB1); multidrug-resistant cancer cell lines; reversal of multidrug resistance; review

Mesh：

Substances：

Year:  2016        PMID： 27793887     DOI： 10.21873/anticanres.11149

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  7 in total

1.  Inducement of apoptosis by cucurbitacin E, a tetracyclic triterpenes, through death receptor 5 in human cervical cancer cell lines.

Authors:  Ya-Min Cheng; Ching-Ju Shen; Chi-Chang Chang; Cheng-Yang Chou; Ching-Chou Tsai; Yi-Chiang Hsu
Journal:  Cell Death Discov       Date:  2017-04-24

Review 2.  Deoxyelephantopin and Isodeoxyelephantopin as Potential Anticancer Agents with Effects on Multiple Signaling Pathways.

Authors:  Tahir Mehmood; Amara Maryam; Hamed A Ghramh; Muhammad Khan; Tonghui Ma
Journal:  Molecules       Date:  2017-06-21       Impact factor: 4.411

Review 3.  Mitocanic Di- and Triterpenoid Rhodamine B Conjugates.

Authors:  Sophie Hoenke; Immo Serbian; Hans-Peter Deigner; René Csuk
Journal:  Molecules       Date:  2020-11-20       Impact factor: 4.411

4.  Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues.

Authors:  Małgorzata Anna Marć; Annamária Kincses; Bálint Rácz; Muhammad Jawad Nasim; Muhammad Sarfraz; Carlos Lázaro-Milla; Enrique Domínguez-Álvarez; Claus Jacob; Gabriella Spengler; Pedro Almendros
Journal:  Pharmaceuticals (Basel)       Date:  2020-12-11

Review 5.  Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action.

Authors:  Tahir Mehmood; Chatchai Muanprasat
Journal:  Molecules       Date:  2022-03-24       Impact factor: 4.411

Review 6.  Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019).

Authors:  Maryam Fattahian; Mustafa Ghanadian; Zulfiqar Ali; Ikhlas A Khan
Journal:  Phytochem Rev       Date:  2020-04-13       Impact factor: 7.741

7.  L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins.

Authors:  Lucia Pavlikova; Mario Seres; Milan Hano; Viera Bohacova; Ivana Sevcikova; Tomas Kyca; Albert Breier; Zdena Sulova
Journal:  Molecules       Date:  2017-07-03       Impact factor: 4.411
  7 in total

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