Literature DB >> 27793196

Life expectancy and healthy life expectancy of Japan: the fastest graying society in the world.

Shinkan Tokudome1, Shuji Hashimoto2, Akihiro Igata3.   

Abstract

BACKGROUND: We appraised time trends of Japanese life expectancy (LE) and healthy life expectancy (HALE) by gender, LE-HALE and (LE-HALE)/LE figures, along with the women-men's differences.
METHODS: Using the Japanese LE and HALE values from 1990 through 2013 by gender in the article by the GBD 2013 DALYs and HALE Collaborators, we examined trends of LE and HALE, and their 5- or 3-year changes. We also probed LE-HALE and (LE-HALE)/LE values, and the women-men's differences.
RESULTS: LE consistently elongated as reported 76.0, 76.5, 77.6, 78.7, 79.3 and 80.1 years for men from 1990 to 2013; and 82.0, 82.8, 84.3, 85.5, 86.1 and 86.4 years for women, respectively. Both time trends demonstrated a significant linear increase (p for trend < 0.001). LE changes were 0.4, 1.1, 1.1, 0.7 and 0.7 years for men, and 0.9, 1.5, 1.2, 0.6 and 0.3 years for women. The trends were statistically significant (p < 0.001), except for 2010-2013 partly due to 3-year interval. HALE also steadily lengthened as seen 68.1, 68.4, 69.1, 69.9, 70.8 and 71.1 years for men from 1990 through 2013; and 72.2, 72.9, 74.0, 74.8, 75.4 and 75.6 years for women. Both time trends showed almost a linear increase (p < 0.05). HALE changes were 0.4, 0.6, 0.8, 0.9 and 0.3 years for men, and 0.7, 1.0, 0.8, 0.6 and 0.2 years for women, without statistical significant trends. LE-HALE values were 8.0, 8.0, 8.5, 8.8, 8.6 and 8.9 years for men; and 9.7, 9.9, 10.4, 10.7, 10.7 and 10.8 years for women. (LE-HALE)/LE figures were 10.5, 10.5, 10.9, 11.1, 10.8 and 11.2% for men, and 11.9, 12.0, 12.3, 12.5, 12.4 and 12.5% for women. LE women-men's differences were 5.9, 6.4, 6.8, 6.8, 6.8 and 6.3 years, and the HALE figures were 4.2, 4.5, 4.9, 4.9, 4.6 and 4.5 years.
CONCLUSIONS: LE and HALE consistently linearly elongated for both sexes over the study period. Not only LE-HALE but also (LE-HALE)/LE values were still growing for both sexes. Public health measures, nursing-care/services as well as social security schemes are called for to further elevate longevities, HALE in particular, and enhance quality of life and well-being.

Entities:  

Keywords:  Healthy life expectancy; Life expectancy; Non-communicable disease; Quality of death; Quality of life

Mesh:

Year:  2016        PMID: 27793196      PMCID: PMC5084424          DOI: 10.1186/s13104-016-2281-2

Source DB:  PubMed          Journal:  BMC Res Notes        ISSN: 1756-0500


Background

Global burden of disease (GBD) and global, regional, and national trends of life expectancy (LE) (the average number of years expected to live at birth) and healthy life expectancy (HALE) [LE taken into account disability-adjusted life-years (DALYs) at birth, disability-free LE, or health-adjusted LE] [1] in the world from 1990 through 2013 were reported by the GBD 2013 DALYs and HALE Collaborators [2, 3]. They provided valuable information on potential sociodemographic factors pertaining to the longevity figures and their transition, and demonstrated global perspectives for achieving sustainable development goals. In addition, they underscored the need for country- and sociodemographic group-specific assessments of the longevity values. Approximately 70 years ago (in 1947), Japanese LE was only ca 50 years for men and 54 years for women [4]. In 2013, Japan attained not only the world’s longest LE of 80.1 years for men and 86.4 years for women, but also the highest HALE of 71.1 years for men and 75.6 years for women [2]. LE of >80 years for men was first achieved in Japan. HALE of >70 years was enjoyed by Japanese men along with the men of Singapore (70.8 years) for the first time worldwide. Thus, it seems informative not only to note trends of LE and HALE by gender, their 5- or 3-year changes [that is, 5 years in length for the first 4 intervals, while 3 years for the last interval (2010–2013)], LE-HALE and (LE-HALE)/LE figures, and their womenmen’s differences but also to discuss public health schemes, nursing-care services, and social security measures thus far implemented (or to be launched) for elevating longevities, HALE in particular, and realizing a better quality of life (QOL) and quality of death (QOD).

Methods

Using the Japanese LE and HALE figures by gender in 1990, 1995, 2000, 2005, 2010 and 2013 in the articles by the GBD 2013 DALYs and HALE Collaborators [2, 3], we probed trends of LE and HALE, along with 5-year changes of 1990–1995, 1995–2000, 2000–2005, 2005–2010 and 3-year change of 2010–2013. We also studied LE-HALE and (LE-HALE)/LE figures, and explored differences in LE and HALE between men and women.

Statistical analyses

On the basis of linear regression model, each trend of LE and HALE from 1990 through 2013 by gender was examined setting respective calendar years as independent variables in consideration of the survey time interval, and assuming the respective longevity indices weighted by inverse variance as dependent variables. Using two-sample z-tests, we statistically probed the 5- or 3-year differences of LE and HALE by gender from 1990 through 2013. Assuming LE and HALE are asymptotically distributed according to normal distribution, we estimated the 95% UIs for LE-HALE and (LE-HALE)/LE values along with gender differences in LE and HALE and similarly examined respective differences. We considered p < 0.05 (two-tailed) as statistically significant.

Results

LE consistently elongated as reported 76.04, 76.45, 77.55, 78.66, 79.34 and 80.05 years for men from 1990 through 2013; and 81.96, 82.84, 84.32, 85.48, 86.09 and 86.39 years for women, in that order (Table 1). Both time trends showed a linear increase, and both gradients were statistically significant (p for trend < 0.001) (Fig. 1). LE 5-year changes (except for 2010-2013) were 0.4, 1.1, 1.1, 0.7 and 0.7 years for men, and 0.9, 1.5, 1.2, 0.6 and 0.3 years for women, with statistical significance (p < 0.001), but not for the last interval due partly to a 3-year difference and wider corresponding 95% UIs.
Table 1

Trends and changes of LE and HALE, LE-HALE and (LE-HALE)/LE, and their gender differences in Japan from 1990 through 2013

Longevity indexCalendar year p for trend
19901990–199519951995–200020002000–200520052005–201020102010–20132013
LE (years)a,b
 Men 76.04 0.4 76.45 1.1 77.55 1.1 78.66 0.7 79.34 0.7 80.05 p < 0.001
 95% UIsc (75.98–76.10) (76.14–76.57) (77.53–77.58) (78.60–78.71) (79.31–79.36) (79.26–80.84)
 Women 81.96 0.9 82.84 1.5 84.32 1.2 85.48 0.6 86.09 0.3 86.39 p < 0.001
 95% UIs (81.86–82.05) (82.62–82.94) (84.29–84.35) (85.41–85.54) (86.06–86.11) (85.74–87.12)
HALE (years)a,b
 Men 68.09 0.4 68.44 0.6 69.08 0.8 69.89 0.9 70.78 0.3 71.11 p < 0.05
 95% UIs (65.83–70.11) (66.07–70.58) (66.67–71.24) (67.31–72.12) (68.20–73.06) (68.50–73.57)
 Women 72.24 0.7 72.92 1.0 73.95 0.8 74.77 0.6 75.41 0.2 75.56 p < 0.05
 95% UIs (69.38–74.77) (70.05–75.49) (70.94–76.55) (71.66–77.46) (72.34–78.23) (72.46–78.42)
LE–HALE (years)
 Men8.08.08.58.88.68.9NS
 95% UIs(5.8–10.1)(5.7–10.3)(6.2–10.8)(6.4–11.2)(6.1–11.0)(6.3–11.6)
 Women9.79.910.410.710.710.8NS
 95% UIs(7.0–12.4)(7.2–12.6)(7.6–13.2)(7.8–13.6)(7.7–13.6)(7.8–13.9)
(LE–HALE)/LE (%)
 Men10.510.510.911.110.811.2NS
 95% UIs(7.6–13.3)(7.5–13.4)(8.0–13.9)(8.1–14.2)(7.7–13.9)(7.9–14.5)
 Women11.912.012.312.512.412.5NS
 95% UIs(8.6–15.2)(8.7–15.3)(9.0–15.6)(9.1–15.9)(9.0–15.8)(9.0–16.1)
LE (years)
 Women–men5.96.46.86.86.86.3 p < 0.001
 95% UIs(5.8–6.0)(6.1–6.7)(6.7–6.8)(6.7–6.9)(6.7–6.8)(5.3–7.4)
HALE (years)
 Women–men4.24.54.94.94.64.5NS
 95% UIs(0.7–7.6)(1.0–8.0)(1.3–8.5)(1.1–8.7)(0.8–8.5)(0.5–8.4)

aHealthy life expectancy from GBD 2013 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life years (DALY) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet, Published online August 27, 2015, http://www.dx.doi.org/10.1016/S0140-6736(15)61340-x

bPersonal communication for the Japanese LE and HALE data of 1995, 2000 and 2010 from Ms. Michelle L. Subart at the Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA (on July 15, 2016)

cUncertainty intervals

Fig. 1

Trends of LE and HALE of Japan from 1990 through 2013

Trends and changes of LE and HALE, LE-HALE and (LE-HALE)/LE, and their gender differences in Japan from 1990 through 2013 aHealthy life expectancy from GBD 2013 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life years (DALY) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet, Published online August 27, 2015, http://www.dx.doi.org/10.1016/S0140-6736(15)61340-x bPersonal communication for the Japanese LE and HALE data of 1995, 2000 and 2010 from Ms. Michelle L. Subart at the Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA (on July 15, 2016) cUncertainty intervals Trends of LE and HALE of Japan from 1990 through 2013 HALE also steadily lengthened as seen 68.09, 68.44, 69.08, 69.89, 70.78 and 71.11 years for men from 1990 through 2013; and 72.24, 72.92, 73.95, 74.77, 75.41 and 75.56 years for women. Both time trends manifested almost a linear increase, and both gradients were statistically significant (p for trend < 0.05). HALE 5-year changes (except for 2010–2013) were 0.4, 0.6, 0.8, 0.9 and 0.3 years for men, and 0.7, 1.0, 0.8, 0.6 and 0.2 years for women, without statistical significance. LE-HALE values were 8.0, 8.0, 8.5, 8.8, 8.6 and 8.9 years for men from 1990 through 2013; and 9.7, 9.9, 10.4, 10.7, 10.7 and 10.8 years for women. (LE-HALE)/LE figures were 10.5, 10.5, 10.9, 11.1, 10.8 and 11.2% for men, and 11.9, 12.0, 12.3, 12.5, 12.4 and 12.5% for women. LE womenmen’s discrepancies were 5.9, 6.4, 6.8, 6.8, 6.8 and 6.3 years, and the HALE figures were 4.2, 4.5, 4.9, 4.9, 4.6 and 4.5 years.

Discussion

Although there was an LE drop in 1995, being partly explained by the Great Hanshin-Awaji Earthquake with 6434 victims and three unidentified people [5], LE consistently elongated for both sexes from 1990 through 2013. LE may be determined in part by genetic diatheses, but mostly by modifiable chronic conditions, health behaviors, and socio-economic and environmental factors [6-9]. For further lengthening LE, the following potential factors are to be taken into account. The traditional well-balanced palatable Japanese cuisine has gradually been changing, but retaining higher salt consumption (10.9 g/day on average for men and 9.2 g/day for women in 2014) [10]. Abundant/imbalanced intakes of energy and nutrients (typically affluent/imbalanced consumption of fats and oils, milk and dairy products, and meat instead of fish/shell fish, but lower intake of calcium) seem to be compatible with enhancing trends of metabolic syndrome (obesity, hypertension, dyslipidemia, and insulin resistance). Smoking rates remain higher among industrialized countries (32.2% in men and 8.5% in women), and tobacco-related cancers and diseases are (and will be) frequent. Although the prevalence of daily drinking is declining, only a small fraction of alcohol-dependent patients had received medical care [10, 11]. Sedentary working style, physical inactivity, and greater motorization are prevailing [10, 12]. The participation rates in annual health checkups in the workplace were high, but rather lower in the community, and population-based cancer screening for several sites (such as the stomach, lung, colorectum, and cervix uteri) stay lower. Mental/psychological health disorders (including depression) are big issues in the workplace due to overtime, stressful working environment and relationship dynamics within the workplace [12, 13]. HALE also manifested an upward increase for both sexes over the study period. Neither p for trend nor the difference of regression coefficient between LE and HALE was significant, but LE-HALE and (LE-HALE)/LE values were steadily gaining, as also reported by Salomon and colleagues that “HALE increased more slowly than did LE [14].” Also of note is that LE-HALE and (LE-HALE)/LE in women were greater than in men, which should be taken into account as they are directly involved in elderly women’s QOL. In turn, Japan ranks high overall, ranking 8th, on the Global AgeWatch Index 2015 [15]. Favorable scores have been attained in two domains (Health domain [including longevities] and Capability domain), but have stayed behind in two domains (Income domain and Enabling societies and environment domain), manifesting age and gender inequities in working opportunity and income, coverage of pension and welfare, and hidden poverty [16]. Namely, HALE may be brought about by not only health-care and rehabilitation but also social security schemes, such as the Pension System, Long-term Nursing-Care, Health and Welfare Services, and Public Assistance [17]. Multi-phasic comprehensive interventions are called for to reduce years lived with disability (YLDs) (i.e., elongate HALE, and compress morbidity or LE-HALE), because people should spend 8.9 YLDs (for men) and 10.8 YLDs (for women) (being more than 10% of the period of his/her life) in poor health. The proportion of the elderly aged 65 years or over was ca 25% in 2013, against 60% for working population aged 15–64 years [18]. The expenditure of benefits for the elderly group is steeply rising, and the burdens of work force and municipal/governmental finance are concurrently growing. Actually, the national health-care expenditure was Jpn Yen 40 trillion [ca US $333 billion (under 1$ = Jpn Yen 120)] in 2014, accounting for more than 40% of the national budget [19]. Japan is facing “the Year 2025 Problem,” when two people in its work force should be able to support one elderly person, and the expenditure will be Jpn Yen 50 trillion (half of the national budget). By this year, as a typical delimiting of time, the baby-boomers will join the old group. Thanks to “low fertility and low mortality,” it is forecast that the proportion of the elderly will be steadily growing, while that of the work force is tapering off, and the ratio is going to increase at least until 2060 [18]. The overall situation appears to be worsening as Japan is clearly moving towards an unheard-of super-aging crisis: too fast for Japanese society to catch-up with. In addition to innovative “core” structural reforms of the national administration and finance, reconstructions of social security plans must be executed, such as deferring of the retirement age, postponing the age for receiving pensions, advanced enrollment of “minorities” (the elderly and women), working on a regular basis, “equal labor, equal pay” for full-time and part-time workers, and effective/efficient use of Public Assistance for the needy elderly [20-22]. Japanese Universal Health Coverage (UHC) (Health Insurance for All, Nationwide Health Insurance Scheme) has largely contributed to enhance HALE as well as LE [20, 21]. The UHC may be a global model of health-care for its low-cost with equity. However, continuing structural reforms of the UHC and health-care service systems have been made for the reduction of health-care costs, withholding of the elderly’s health-care benefits, and so forth. Shared risk communication and securing a second opinion seem essential, but it is troublesome to realize that the UHC allows free and/or redundant (at times useless/unnecessary) visits to medical clinics/facilities, and repeated medical examinations and medicines [23]. The family/general physician system is developing, but the Medical Care Zone Scheme is not necessarily working well [21, 24]. Using the Social Security and Tax Number System (My Number System) just enacted [25], the reduction of health-care costs could partly be achieved by record linkage with electronic health records to be stored in a unique IC card (or in cloud computing). Needless to say, this system must be launched under a national consensus, and should be handled under strict security and confidentiality. QOL now includes several aspects; not only quality of biological life and quality of daily life but also quality of existence are of importance to fulfill one’s life, to live and die with dignity, and to finally realize better QOD. Recently, the Economist Intelligent Unit of the UK Economist magazine ranked Japan’s QOD index 2015 as 14th in the world [26]. The profiles of Japanese Affordability of care, Quality of care, and Community engagement were satisfactory, while those of Human resources and Palliative and health-care environment were rather unsatisfactory, so the ameliorations are urgent. Much remains to be improved in terms of QOD as well as HALE and QOL from the aspect of the well-being index of the elderly.

Conclusions

Japan has achieved the world’s longest HALE as well as LE for both sexes in 2013. The increasing trends from 1990 through 2013, and significant changes were still being demonstrated. Not only long-term health-care strategies but also comprehensive community health promotion and social security services should be undertaken to further reduce mortality gap/health gap, elevate HALE, and enhance QOL and QOD in Japan.
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Francisco A García-Guerra; Evariste Gasana; Johanna M Geleijnse; Bradford D Gessner; Pete Gething; Katherine B Gibney; Richard F Gillum; Ibrahim A M Ginawi; Maurice Giroud; Giorgia Giussani; Shifalika Goenka; Ketevan Goginashvili; Hector Gomez Dantes; Philimon Gona; Teresita Gonzalez de Cosio; Dinorah González-Castell; Carolyn C Gotay; Atsushi Goto; Hebe N Gouda; Richard L Guerrant; Harish C Gugnani; Francis Guillemin; David Gunnell; Rahul Gupta; Rajeev Gupta; Reyna A Gutiérrez; Nima Hafezi-Nejad; Holly Hagan; Maria Hagstromer; Yara A Halasa; Randah R Hamadeh; Mouhanad Hammami; Graeme J Hankey; Yuantao Hao; Hilda L Harb; Tilahun Nigatu Haregu; Josep Maria Haro; Rasmus Havmoeller; Simon I Hay; Mohammad T Hedayati; Ileana B Heredia-Pi; Lucia Hernandez; Kyle R Heuton; Pouria Heydarpour; Martha Hijar; Hans W Hoek; Howard J Hoffman; John C Hornberger; H Dean Hosgood; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; Howard Hu; Cheng Huang; John J Huang; Bryan J Hubbell; Laetitia Huiart; Abdullatif Husseini; Marissa L Iannarone; Kim M Iburg; Bulat T Idrisov; Nayu Ikeda; Kaire Innos; Manami Inoue; Farhad Islami; Samaya Ismayilova; Kathryn H Jacobsen; Henrica A Jansen; Deborah L Jarvis; Simerjot K Jassal; Alejandra Jauregui; Sudha Jayaraman; Panniyammakal Jeemon; Paul N Jensen; Vivekanand Jha; Fan Jiang; Guohong Jiang; Ying Jiang; Jost B Jonas; Knud Juel; Haidong Kan; Sidibe S Kany Roseline; Nadim E Karam; André Karch; Corine K Karema; Ganesan Karthikeyan; Anil Kaul; Norito Kawakami; Dhruv S Kazi; Andrew H Kemp; Andre P Kengne; Andre Keren; Yousef S Khader; Shams Eldin Ali Hassan Khalifa; Ejaz A Khan; Young-Ho Khang; Shahab Khatibzadeh; Irma Khonelidze; Christian Kieling; Daniel Kim; Sungroul Kim; Yunjin Kim; Ruth W Kimokoti; Yohannes Kinfu; Jonas M Kinge; Brett M Kissela; Miia Kivipelto; Luke D Knibbs; Ann Kristin Knudsen; Yoshihiro Kokubo; M Rifat Kose; Soewarta Kosen; Alexander Kraemer; Michael Kravchenko; Sanjay Krishnaswami; Hans Kromhout; Tiffany Ku; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Ernst J Kuipers; Chanda Kulkarni; Veena S Kulkarni; G Anil Kumar; Gene F Kwan; Taavi Lai; Arjun Lakshmana Balaji; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Qing Lan; Van C Lansingh; Heidi J Larson; Anders Larsson; Dennis O Laryea; Pablo M Lavados; Alicia E Lawrynowicz; Janet L Leasher; Jong-Tae Lee; James Leigh; Ricky Leung; Miriam Levi; Yichong Li; Yongmei Li; Juan Liang; Xiaofeng Liang; Stephen S Lim; M Patrice Lindsay; Steven E Lipshultz; Shiwei Liu; Yang Liu; Belinda K Lloyd; Giancarlo Logroscino; Stephanie J London; Nancy Lopez; Joannie Lortet-Tieulent; Paulo A Lotufo; Rafael Lozano; Raimundas Lunevicius; Jixiang Ma; Stefan Ma; Vasco M P Machado; Michael F MacIntyre; Carlos Magis-Rodriguez; Abbas A Mahdi; Marek Majdan; Reza Malekzadeh; Srikanth Mangalam; Christopher C Mapoma; Marape Marape; Wagner Marcenes; David J Margolis; Christopher Margono; Guy B Marks; Randall V Martin; Melvin B Marzan; Mohammad T Mashal; Felix Masiye; Amanda J Mason-Jones; Kunihiro Matsushita; Richard Matzopoulos; Bongani M Mayosi; Tasara T Mazorodze; Abigail C McKay; Martin McKee; Abigail McLain; Peter A Meaney; Catalina Medina; Man Mohan Mehndiratta; Fabiola Mejia-Rodriguez; Wubegzier Mekonnen; Yohannes A Melaku; Michele Meltzer; Ziad A Memish; Walter Mendoza; George A Mensah; Atte Meretoja; Francis Apolinary Mhimbira; Renata Micha; Ted R Miller; Edward J Mills; Awoke Misganaw; Santosh Mishra; Norlinah Mohamed Ibrahim; Karzan A Mohammad; Ali H Mokdad; Glen L Mola; Lorenzo Monasta; Julio C Montañez Hernandez; Marcella Montico; Ami R Moore; Lidia Morawska; Rintaro Mori; Joanna Moschandreas; Wilkister N Moturi; Dariush Mozaffarian; Ulrich O Mueller; Mitsuru Mukaigawara; Erin C Mullany; Kinnari S Murthy; Mohsen Naghavi; Ziad Nahas; Aliya Naheed; Kovin S Naidoo; Luigi Naldi; Devina Nand; Vinay Nangia; K M Venkat Narayan; Denis Nash; Bruce Neal; Chakib Nejjari; Sudan P Neupane; Charles R Newton; Frida N Ngalesoni; Jean de Dieu Ngirabega; Grant Nguyen; Nhung T Nguyen; Mark J Nieuwenhuijsen; Muhammad I Nisar; José R Nogueira; Joan M Nolla; Sandra Nolte; Ole F Norheim; Rosana E Norman; Bo Norrving; Luke Nyakarahuka; In-Hwan Oh; Takayoshi Ohkubo; Bolajoko O Olusanya; Saad B Omer; John Nelson Opio; Ricardo Orozco; Rodolfo S Pagcatipunan; Amanda W Pain; Jeyaraj D Pandian; Carlo Irwin A Panelo; Christina Papachristou; Eun-Kee Park; Charles D Parry; Angel J Paternina Caicedo; Scott B Patten; Vinod K Paul; Boris I Pavlin; Neil Pearce; Lilia S Pedraza; Andrea Pedroza; Ljiljana Pejin Stokic; Ayfer Pekericli; David M Pereira; Rogelio Perez-Padilla; Fernando Perez-Ruiz; Norberto Perico; Samuel A L Perry; Aslam Pervaiz; Konrad Pesudovs; Carrie B Peterson; Max Petzold; Michael R Phillips; Hwee Pin Phua; Dietrich Plass; Dan Poenaru; Guilherme V Polanczyk; Suzanne Polinder; Constance D Pond; C Arden Pope; Daniel Pope; Svetlana Popova; Farshad Pourmalek; John Powles; Dorairaj Prabhakaran; Noela M Prasad; Dima M Qato; Amado D Quezada; D Alex A Quistberg; Lionel Racapé; Anwar Rafay; Kazem Rahimi; Vafa Rahimi-Movaghar; Sajjad Ur Rahman; Murugesan Raju; Ivo Rakovac; Saleem M Rana; Mayuree Rao; Homie Razavi; K Srinath Reddy; Amany H Refaat; Jürgen Rehm; Giuseppe Remuzzi; Antonio L Ribeiro; Patricia M Riccio; Lee Richardson; Anne Riederer; Margaret Robinson; Anna Roca; Alina Rodriguez; David Rojas-Rueda; Isabelle Romieu; Luca Ronfani; Robin Room; Nobhojit Roy; George M Ruhago; Lesley Rushton; Nsanzimana Sabin; Ralph L Sacco; Sukanta Saha; Ramesh Sahathevan; Mohammad Ali Sahraian; Joshua A Salomon; Deborah Salvo; Uchechukwu K Sampson; Juan R Sanabria; Luz Maria Sanchez; Tania G Sánchez-Pimienta; Lidia Sanchez-Riera; Logan Sandar; Itamar S Santos; Amir Sapkota; Maheswar Satpathy; James E Saunders; Monika Sawhney; Mete I Saylan; Peter Scarborough; Jürgen C Schmidt; Ione J C Schneider; Ben Schöttker; David C Schwebel; James G Scott; Soraya Seedat; Sadaf G Sepanlou; Berrin Serdar; Edson E Servan-Mori; Gavin Shaddick; Saeid Shahraz; Teresa Shamah Levy; Siyi Shangguan; Jun She; Sara Sheikhbahaei; Kenji Shibuya; Hwashin H Shin; Yukito Shinohara; Rahman Shiri; Kawkab Shishani; Ivy Shiue; Inga D Sigfusdottir; Donald H Silberberg; Edgar P Simard; Shireen Sindi; Abhishek Singh; Gitanjali M Singh; Jasvinder A Singh; Vegard Skirbekk; Karen Sliwa; Michael Soljak; Samir Soneji; Kjetil Søreide; Sergey Soshnikov; Luciano A Sposato; Chandrashekhar T Sreeramareddy; Nicolas J C Stapelberg; Vasiliki Stathopoulou; Nadine Steckling; Dan J Stein; Murray B Stein; Natalie Stephens; Heidi Stöckl; Kurt Straif; Konstantinos Stroumpoulis; Lela Sturua; Bruno F Sunguya; Soumya Swaminathan; Mamta Swaroop; Bryan L Sykes; Karen M Tabb; Ken Takahashi; Roberto T Talongwa; Nikhil Tandon; David Tanne; Marcel Tanner; Mohammad Tavakkoli; Braden J Te Ao; Carolina M Teixeira; Martha M Téllez Rojo; Abdullah S Terkawi; José Luis Texcalac-Sangrador; Sarah V Thackway; Blake Thomson; Andrew L Thorne-Lyman; Amanda G Thrift; George D Thurston; Taavi Tillmann; Myriam Tobollik; Marcello Tonelli; Fotis Topouzis; Jeffrey A Towbin; Hideaki Toyoshima; Jefferson Traebert; Bach X Tran; Leonardo Trasande; Matias Trillini; Ulises Trujillo; Zacharie Tsala Dimbuene; Miltiadis Tsilimbaris; Emin Murat Tuzcu; Uche S Uchendu; Kingsley N Ukwaja; Selen B Uzun; Steven van de Vijver; Rita Van Dingenen; Coen H van Gool; Jim van Os; Yuri Y Varakin; Tommi J Vasankari; Ana Maria N Vasconcelos; Monica S Vavilala; Lennert J Veerman; Gustavo Velasquez-Melendez; N Venketasubramanian; Lakshmi Vijayakumar; Salvador Villalpando; Francesco S Violante; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Gregory R Wagner; Stephen G Waller; Mitchell T Wallin; Xia Wan; Haidong Wang; JianLi Wang; Linhong Wang; Wenzhi Wang; Yanping Wang; Tati S Warouw; Charlotte H Watts; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Andrea Werdecker; K Ryan Wessells; Ronny Westerman; Harvey A Whiteford; James D Wilkinson; Hywel C Williams; Thomas N Williams; Solomon M Woldeyohannes; Charles D A Wolfe; John Q Wong; Anthony D Woolf; Jonathan L Wright; Brittany Wurtz; Gelin Xu; Lijing L Yan; Gonghuan Yang; Yuichiro Yano; Pengpeng Ye; Muluken Yenesew; Gökalp K Yentür; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Zourkaleini Younoussi; Chuanhua Yu; Maysaa E Zaki; Yong Zhao; Yingfeng Zheng; Maigeng Zhou; Jun Zhu; Shankuan Zhu; Xiaonong Zou; Joseph R Zunt; Alan D Lopez; Theo Vos; Christopher J Murray
Journal:  Lancet       Date:  2015-09-11       Impact factor: 79.321

9.  Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

Authors:  Christopher J L Murray; Ryan M Barber; Kyle J Foreman; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Semaw F Abera; Victor Aboyans; Jerry P Abraham; Ibrahim Abubakar; Laith J Abu-Raddad; Niveen M Abu-Rmeileh; Tom Achoki; Ilana N Ackerman; Zanfina Ademi; Arsène K Adou; José C Adsuar; Ashkan Afshin; Emilie E Agardh; Sayed Saidul Alam; Deena Alasfoor; Mohammed I Albittar; Miguel A Alegretti; Zewdie A Alemu; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; François Alla; Peter Allebeck; Mohammad A Almazroa; Ubai Alsharif; Elena Alvarez; Nelson Alvis-Guzman; Azmeraw T Amare; Emmanuel A Ameh; Heresh Amini; Walid Ammar; H Ross Anderson; Benjamin O Anderson; Carl Abelardo T Antonio; Palwasha Anwari; Johan Arnlöv; Valentina S Arsic Arsenijevic; Al Artaman; Rana J Asghar; Reza Assadi; Lydia S Atkins; Marco A Avila; Baffour Awuah; Victoria F Bachman; Alaa Badawi; Maria C Bahit; Kalpana Balakrishnan; Amitava Banerjee; Suzanne L Barker-Collo; Simon Barquera; Lars Barregard; Lope H Barrero; Arindam Basu; Sanjay Basu; Mohammed O Basulaiman; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Tolesa Bekele; Michelle L Bell; Corina Benjet; Derrick A Bennett; Isabela M Bensenor; Habib Benzian; Eduardo Bernabé; Amelia Bertozzi-Villa; Tariku J Beyene; Neeraj Bhala; Ashish Bhalla; Zulfiqar A Bhutta; Kelly Bienhoff; Boris Bikbov; Stan Biryukov; Jed D Blore; Christopher D Blosser; Fiona M Blyth; Megan A Bohensky; Ian W Bolliger; Berrak Bora Başara; Natan M Bornstein; Dipan Bose; Soufiane Boufous; Rupert R A Bourne; Lindsay N Boyers; Michael Brainin; Carol E Brayne; Alexandra Brazinova; Nicholas J K Breitborde; Hermann Brenner; Adam D Briggs; Peter M Brooks; Jonathan C Brown; Traolach S Brugha; Rachelle Buchbinder; Geoffrey C Buckle; Christine M Budke; Anne Bulchis; Andrew G Bulloch; Ismael R Campos-Nonato; Hélène Carabin; Jonathan R Carapetis; Rosario Cárdenas; David O Carpenter; Valeria Caso; Carlos A Castañeda-Orjuela; Ruben E Castro; Ferrán Catalá-López; Fiorella Cavalleri; Alanur Çavlin; Vineet K Chadha; Jung-Chen Chang; Fiona J Charlson; Honglei Chen; Wanqing Chen; Peggy P Chiang; Odgerel Chimed-Ochir; Rajiv Chowdhury; Hanne Christensen; Costas A Christophi; Massimo Cirillo; Matthew M Coates; Luc E Coffeng; Megan S Coggeshall; Valentina Colistro; Samantha M Colquhoun; Graham S Cooke; Cyrus Cooper; Leslie T Cooper; Luis M Coppola; Monica Cortinovis; Michael H Criqui; John A Crump; Lucia Cuevas-Nasu; Hadi Danawi; Lalit Dandona; Rakhi Dandona; Emily Dansereau; Paul I Dargan; Gail Davey; Adrian Davis; Dragos V Davitoiu; Anand Dayama; Diego De Leo; Louisa Degenhardt; Borja Del Pozo-Cruz; Robert P Dellavalle; Kebede Deribe; Sarah Derrett; Don C Des Jarlais; Muluken Dessalegn; Samath D Dharmaratne; Mukesh K Dherani; Cesar Diaz-Torné; Daniel Dicker; Eric L Ding; Klara Dokova; E Ray Dorsey; Tim R Driscoll; Leilei Duan; Herbert C Duber; Beth E Ebel; Karen M Edmond; Yousef M Elshrek; Matthias Endres; Sergey P Ermakov; Holly E Erskine; Babak Eshrati; Alireza Esteghamati; Kara Estep; Emerito Jose A Faraon; Farshad Farzadfar; Derek F Fay; Valery L Feigin; David T Felson; Seyed-Mohammad Fereshtehnejad; Jefferson G Fernandes; Alize J Ferrari; Christina Fitzmaurice; Abraham D Flaxman; Thomas D Fleming; Nataliya Foigt; Mohammad H Forouzanfar; F Gerry R Fowkes; Urbano Fra Paleo; Richard C Franklin; Thomas Fürst; Belinda Gabbe; Lynne Gaffikin; Fortuné G Gankpé; Johanna M Geleijnse; Bradford D Gessner; Peter Gething; Katherine B Gibney; Maurice Giroud; Giorgia Giussani; Hector Gomez Dantes; Philimon Gona; Diego González-Medina; Richard A Gosselin; Carolyn C Gotay; Atsushi Goto; Hebe N Gouda; Nicholas Graetz; Harish C Gugnani; Rahul Gupta; Rajeev Gupta; Reyna A Gutiérrez; Juanita Haagsma; Nima Hafezi-Nejad; Holly Hagan; Yara A Halasa; Randah R Hamadeh; Hannah Hamavid; Mouhanad Hammami; Jamie Hancock; Graeme J Hankey; Gillian M Hansen; Yuantao Hao; Hilda L Harb; Josep Maria Haro; Rasmus Havmoeller; Simon I Hay; Roderick J Hay; Ileana B Heredia-Pi; Kyle R Heuton; Pouria Heydarpour; Hideki Higashi; Martha Hijar; Hans W Hoek; Howard J Hoffman; H Dean Hosgood; Mazeda Hossain; Peter J Hotez; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; Cheng Huang; John J Huang; Abdullatif Husseini; Chantal Huynh; Marissa L Iannarone; Kim M Iburg; Kaire Innos; Manami Inoue; Farhad Islami; Kathryn H Jacobsen; Deborah L Jarvis; Simerjot K Jassal; Sun Ha Jee; Panniyammakal Jeemon; Paul N Jensen; Vivekanand Jha; Guohong Jiang; Ying Jiang; Jost B Jonas; Knud Juel; Haidong Kan; André Karch; Corine K Karema; Chante Karimkhani; Ganesan Karthikeyan; Nicholas J Kassebaum; Anil Kaul; Norito Kawakami; Konstantin Kazanjan; Andrew H Kemp; Andre P Kengne; Andre Keren; Yousef S Khader; Shams Eldin A Khalifa; Ejaz A Khan; Gulfaraz Khan; Young-Ho Khang; Christian Kieling; Daniel Kim; Sungroul Kim; Yunjin Kim; Yohannes Kinfu; Jonas M Kinge; Miia Kivipelto; Luke D Knibbs; Ann Kristin Knudsen; Yoshihiro Kokubo; Soewarta Kosen; Sanjay Krishnaswami; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Ernst J Kuipers; Chanda Kulkarni; Veena S Kulkarni; G Anil Kumar; Hmwe H Kyu; Taavi Lai; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Qing Lan; Van C Lansingh; Anders Larsson; Alicia E B Lawrynowicz; Janet L Leasher; James Leigh; Ricky Leung; Carly E Levitz; Bin Li; Yichong Li; Yongmei Li; Stephen S Lim; Maggie Lind; Steven E Lipshultz; Shiwei Liu; Yang Liu; Belinda K Lloyd; Katherine T Lofgren; Giancarlo Logroscino; Katharine J Looker; Joannie Lortet-Tieulent; Paulo A Lotufo; Rafael Lozano; Robyn M Lucas; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Michael F Macintyre; Mark T Mackay; Marek Majdan; Reza Malekzadeh; Wagner Marcenes; David J Margolis; Christopher Margono; Melvin B Marzan; Joseph R Masci; Mohammad T Mashal; Richard Matzopoulos; Bongani M Mayosi; Tasara T Mazorodze; Neil W Mcgill; John J Mcgrath; Martin Mckee; Abigail Mclain; Peter A Meaney; Catalina Medina; Man Mohan Mehndiratta; Wubegzier Mekonnen; Yohannes A Melaku; Michele Meltzer; Ziad A Memish; George A Mensah; Atte Meretoja; Francis A Mhimbira; Renata Micha; Ted R Miller; Edward J Mills; Philip B Mitchell; Charles N Mock; Norlinah Mohamed Ibrahim; Karzan A Mohammad; Ali H Mokdad; Glen L D Mola; Lorenzo Monasta; Julio C Montañez Hernandez; Marcella Montico; Thomas J Montine; Meghan D Mooney; Ami R Moore; Maziar Moradi-Lakeh; Andrew E Moran; Rintaro Mori; Joanna Moschandreas; Wilkister N Moturi; Madeline L Moyer; Dariush Mozaffarian; William T Msemburi; Ulrich O Mueller; Mitsuru Mukaigawara; Erin C Mullany; Michele E Murdoch; Joseph Murray; Kinnari S Murthy; Mohsen Naghavi; Aliya Naheed; Kovin S Naidoo; Luigi Naldi; Devina Nand; Vinay Nangia; K M Venkat Narayan; Chakib Nejjari; Sudan P Neupane; Charles R Newton; Marie Ng; Frida N Ngalesoni; Grant Nguyen; Muhammad I Nisar; Sandra Nolte; Ole F Norheim; Rosana E Norman; Bo Norrving; Luke Nyakarahuka; In-Hwan Oh; Takayoshi Ohkubo; Summer L Ohno; Bolajoko O Olusanya; John Nelson Opio; Katrina Ortblad; Alberto Ortiz; Amanda W Pain; Jeyaraj D Pandian; Carlo Irwin A Panelo; Christina Papachristou; Eun-Kee Park; Jae-Hyun Park; Scott B Patten; George C Patton; Vinod K Paul; Boris I Pavlin; Neil Pearce; David M Pereira; Rogelio Perez-Padilla; Fernando Perez-Ruiz; Norberto Perico; Aslam Pervaiz; Konrad Pesudovs; Carrie B Peterson; Max Petzold; Michael R Phillips; Bryan K Phillips; David E Phillips; Frédéric B Piel; Dietrich Plass; Dan Poenaru; Suzanne Polinder; Daniel Pope; Svetlana Popova; Richie G Poulton; Farshad Pourmalek; Dorairaj Prabhakaran; Noela M Prasad; Rachel L Pullan; Dima M Qato; D Alex Quistberg; Anwar Rafay; Kazem Rahimi; Sajjad U Rahman; Murugesan Raju; Saleem M Rana; Homie Razavi; K Srinath Reddy; Amany Refaat; Giuseppe Remuzzi; Serge Resnikoff; Antonio L Ribeiro; Lee Richardson; Jan Hendrik Richardus; D Allen Roberts; David Rojas-Rueda; Luca Ronfani; Gregory A Roth; Dietrich Rothenbacher; David H Rothstein; Jane T Rowley; Nobhojit Roy; George M Ruhago; Mohammad Y Saeedi; Sukanta Saha; Mohammad Ali Sahraian; Uchechukwu K A Sampson; Juan R Sanabria; Logan Sandar; Itamar S Santos; Maheswar Satpathy; Monika Sawhney; Peter Scarborough; Ione J Schneider; Ben Schöttker; Austin E Schumacher; David C Schwebel; James G Scott; Soraya Seedat; Sadaf G Sepanlou; Peter T Serina; Edson E Servan-Mori; Katya A Shackelford; Amira Shaheen; Saeid Shahraz; Teresa Shamah Levy; Siyi Shangguan; Jun She; Sara Sheikhbahaei; Peilin Shi; Kenji Shibuya; Yukito Shinohara; Rahman Shiri; Kawkab Shishani; Ivy Shiue; Mark G Shrime; Inga D Sigfusdottir; Donald H Silberberg; Edgar P Simard; Shireen Sindi; Abhishek Singh; Jasvinder A Singh; Lavanya Singh; Vegard Skirbekk; Erica Leigh Slepak; Karen Sliwa; Samir Soneji; Kjetil Søreide; Sergey Soshnikov; Luciano A Sposato; Chandrashekhar T Sreeramareddy; Jeffrey D Stanaway; Vasiliki Stathopoulou; Dan J Stein; Murray B Stein; Caitlyn Steiner; Timothy J Steiner; Antony Stevens; Andrea Stewart; Lars J Stovner; Konstantinos Stroumpoulis; Bruno F Sunguya; Soumya Swaminathan; Mamta Swaroop; Bryan L Sykes; Karen M Tabb; Ken Takahashi; Nikhil Tandon; David Tanne; Marcel Tanner; Mohammad Tavakkoli; Hugh R Taylor; Braden J Te Ao; Fabrizio Tediosi; Awoke M Temesgen; Tara Templin; Margreet Ten Have; Eric Y Tenkorang; Abdullah S Terkawi; Blake Thomson; Andrew L Thorne-Lyman; Amanda G Thrift; George D Thurston; Taavi Tillmann; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach X Tran; Matias Trillini; Thomas Truelsen; Miltiadis Tsilimbaris; Emin M Tuzcu; Uche S Uchendu; Kingsley N Ukwaja; Eduardo A Undurraga; Selen B Uzun; Wim H Van Brakel; Steven Van De Vijver; Coen H van Gool; Jim Van Os; Tommi J Vasankari; N Venketasubramanian; Francesco S Violante; Vasiliy V Vlassov; Stein Emil Vollset; Gregory R Wagner; Joseph Wagner; Stephen G Waller; Xia Wan; Haidong Wang; Jianli Wang; Linhong Wang; Tati S Warouw; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Wang Wenzhi; Andrea Werdecker; Ronny Westerman; Harvey A Whiteford; James D Wilkinson; Thomas N Williams; Charles D Wolfe; Timothy M Wolock; Anthony D Woolf; Sarah Wulf; Brittany Wurtz; Gelin Xu; Lijing L Yan; Yuichiro Yano; Pengpeng Ye; Gökalp K Yentür; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Chuanhua Yu; Maysaa E Zaki; Yong Zhao; Yingfeng Zheng; David Zonies; Xiaonong Zou; Joshua A Salomon; Alan D Lopez; Theo Vos
Journal:  Lancet       Date:  2015-08-28       Impact factor: 79.321

  9 in total
  14 in total

1.  The role of Perioperative Surgical Home on health and longevity in society: importance of the surgical prehabilitation program.

Authors:  Masahiko Kawaguchi; Mitsuru Ida; Yusuke Naito
Journal:  J Anesth       Date:  2017-03-03       Impact factor: 2.078

2.  Predictors Associated with Survival Among Elderly In-Patients Who Receive Cardiopulmonary Resuscitation in Japan: An Observational Cohort Study.

Authors:  Tetsuro Hayashi; Masato Matsushima; Seiji Bito; Natsuko Kanazawa; Norihiko Inoue; Sarah Kyuragi Luthe; Christina C Wee
Journal:  J Gen Intern Med       Date:  2018-11-27       Impact factor: 5.128

3.  The association between somatic and psychological discomfort and health-related quality of life according to the elderly and non-elderly.

Authors:  Hyeon-Sook Lee; Siwoo Lee; Sohee Park; Younghwa Baek; Ji-Hye Youn; Dan Bee Cho; Jung-Hyun Jin; Aesun Shin; Sue K Park; Keon Wook Kang; Young-Khi Lim; Chul Hwan Kang; Keun-Young Yoo; Kwang-Pil Ko
Journal:  Qual Life Res       Date:  2017-10-12       Impact factor: 4.147

4.  Trends in health expectancies: a systematic review of international evidence.

Authors:  Gemma F Spiers; Tafadzwa Patience Kunonga; Fiona Beyer; Dawn Craig; Barbara Hanratty; Carol Jagger
Journal:  BMJ Open       Date:  2021-05-25       Impact factor: 2.692

5.  Effects of Exercise Training Combined with Increased Physical Activity to Prevent Chronic Pain in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial.

Authors:  Tatsuya Hirase; Hideki Kataoka; Shigeru Inokuchi; Jiro Nakano; Junya Sakamoto; Minoru Okita
Journal:  Pain Res Manag       Date:  2018-04-05       Impact factor: 3.037

6.  Health Observation App for COVID-19 Symptom Tracking Integrated With Personal Health Records: Proof of Concept and Practical Use Study.

Authors:  Keiichi Yamamoto; Tsubasa Takahashi; Miwa Urasaki; Yoichi Nagayasu; Tomonari Shimamoto; Yukiko Tateyama; Keiichi Matsuzaki; Daisuke Kobayashi; Satoshi Kubo; Shigeyuki Mito; Tatsuya Abe; Hideo Matsuura; Taku Iwami
Journal:  JMIR Mhealth Uhealth       Date:  2020-07-06       Impact factor: 4.773

7.  Declined Functional Status Prolonged Hospital Stay for Community-Acquired Pneumonia in Seniors.

Authors:  Hao Chen; Yu Hara; Nobuyuki Horita; Yusuke Saigusa; Yoshihiro Hirai; Takeshi Kaneko
Journal:  Clin Interv Aging       Date:  2020-08-27       Impact factor: 4.458

Review 8.  Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging.

Authors:  Sára Sándor; Enikő Kubinyi
Journal:  Front Genet       Date:  2019-10-18       Impact factor: 4.599

9.  Household Income Relationship With Health Services Utilization and Healthcare Expenditures in People Aged 75 Years or Older in Japan: A Population-Based Study Using Medical and Long-term Care Insurance Claims Data.

Authors:  Shota Hamada; Hideto Takahashi; Nobuo Sakata; Boyoung Jeon; Takahiro Mori; Katsuya Iijima; Satoru Yoshie; Tatsuro Ishizaki; Nanako Tamiya
Journal:  J Epidemiol       Date:  2018-09-22       Impact factor: 3.211

10.  Comparing the differences in three measures of healthy life expectancy among prefectures in Japan.

Authors:  Kazuya Taira; Soshiro Ogata; Kei Kamide
Journal:  BMC Res Notes       Date:  2020-08-05
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