Literature DB >> 2779263

A mathematical model of the kinetics of blood coagulation.

M A Khanin1, V V Semenov.   

Abstract

Linear mathematical models of the kinetics of blood coagulation have previously been presented (Levine, 1966, Science, N.Y. 152, 651; Martorana & Moro, 1974, Math. Biosci. 21, 77). In this paper a non-linear mathematical model of the extrinsic pathway of blood coagulation is presented to take into account a positive feedback. The feedback is due to factor Va as a co-factor involved in thrombin formation. The extrinsic pathway is shown to function as an amplifier cascade if a vessel wall injury exceeds a threshold value. For sub-threshold stimulation, the extrinsic pathway does not function.

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Year:  1989        PMID： 2779263     DOI： 10.1016/s0022-5193(89)80220-6

Source DB:  PubMed          Journal:  J Theor Biol        ISSN： 0022-5193            Impact factor:   2.691


  8 in total

1.  A mathematical model of the background state of the blood coagulation system.

Authors:  I F Obraztsov; D V Kardakov; A E Kogan; M A Khanin
Journal:  Dokl Biochem Biophys       Date:  2001 Jan-Feb       Impact factor: 0.788

2.  Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation.

Authors:  Mikhail A Panteleev; Anna N Balandina; Elena N Lipets; Mikhail V Ovanesov; Fazoil I Ataullakhanov
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

3.  Positive feedback loops for factor V and factor VII activation supply sensitivity to local surface tissue factor density during blood coagulation.

Authors:  A N Balandina; A M Shibeko; D A Kireev; A A Novikova; I I Shmirev; M A Panteleev; F I Ataullakhanov
Journal:  Biophys J       Date:  2011-10-19       Impact factor: 4.033

4.  A multiscale model of thrombus development.

Authors:  Zhiliang Xu; Nan Chen; Malgorzata M Kamocka; Elliot D Rosen; Mark Alber
Journal:  J R Soc Interface       Date:  2008-07-06       Impact factor: 4.118

5.  Biochemomechanics of cerebral vasospasm and its resolution: I. A new hypothesis and theoretical framework.

Authors:  J D Humphrey; S Baek; L E Niklason
Journal:  Ann Biomed Eng       Date:  2007-05-09       Impact factor: 3.934

Review 6.  Contact activation of blood-plasma coagulation.

Authors:  Erwin A Vogler; Christopher A Siedlecki
Journal:  Biomaterials       Date:  2009-01-24       Impact factor: 12.479

7.  A Systems Pharmacology Model for Predicting Effects of Factor Xa Inhibitors in Healthy Subjects: Assessment of Pharmacokinetics and Binding Kinetics.

Authors:  X Zhou; Drh Huntjens; Rahj Gilissen
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2015-10-09

8.  Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.

Authors:  Joanne L Dunster; Francoise Mazet; Michael J Fry; Jonathan M Gibbins; Marcus J Tindall
Journal:  PLoS Comput Biol       Date:  2015-11-19       Impact factor: 4.475
  8 in total

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