Microparticles to enhance delivery of drugs and growth factors into wound sites.

Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.