Dominik Steubl1, Matthias Block2, Victor Herbst2, Wolfgang Schlumberger2, Andreas Nockher3, Susanne Angermann1, Christoph Schmaderer1, Uwe Heemann1, Lutz Renders1, Jürgen Scherberich4. 1. a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany. 2. b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany. 3. c Institute of Laboratory Medicine and Pathobiochemistry , Universitätsklinikum Marburg, Philipps-Universität Marburg , Marburg , Germany. 4. d Department of Nephrology and Clinical Immunology, Klinikum München-Harlaching , Teaching Hospital of the Ludwig-Maximilian-Universität , München , Germany.
Abstract
OBJECTIVE AND METHODS: Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. RESULTS: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. CONCLUSION: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.
OBJECTIVE AND METHODS: Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. RESULTS: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. CONCLUSION: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.
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