| Literature DB >> 27790713 |
T Zou1,2, X Mao1,2, J Yin1,2, X Li1,2, J Chen1,2, T Zhu1,2, Q Li1,2, H Zhou1,2, Z Liu1,2.
Abstract
The Ras-related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family of small guanosine triphosphatases, is critical for many cellular activities, such as phagocytosis, adhesion, migration, motility, cell proliferation, and axonal growth. In addition, RAC1 plays an important role in cancer angiogenesis, invasion, and migration, and it has been reported to be related to most cancers, such as breast cancer, gastric cancer, testicular germ cell cancer, and lung cancer. Recently, the therapeutic target of RAC1 in cancer has been investigated. In addition, some investigations have shown that inhibition of RAC1 can reverse drug-resistance in non-small cell lung cancer. In this review, we summarize the recent advances in understanding the role of RAC1 in lung cancer and the underlying mechanisms and discuss its value in clinical therapy.Entities:
Keywords: RAC1; cell proliferation and apoptosis; invasion; lung cancer; migration
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Year: 2016 PMID： 27790713 DOI： 10.1111/cge.12908
Source DB: PubMed Journal: Clin Genet ISSN： 0009-9163 Impact factor: 4.438