Mozhdeh Zamani1, Seyed Vahid Hosseini1, Pooneh Mokarram2,3. 1. a Colorectal Research Center , Shiraz University of Medical Sciences , Shiraz , IR Iran. 2. b Gasteroenterohepatology Research Center , Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran. 3. c Department of Biochemistry, Faculty of Medicine , Shiraz University of Medical Sciences , Shiraz , Iran.
Abstract
CONTEXT: Colorectal cancer is one of the most common cancers worldwide. Epigenetic alterations play an important role in the pathogenesis of the colorectal cancer. OBJECTIVE: This review has focused on the most recent investigations, which has suggested potential epigenetic biomarkers in colorectal cancer. METHODS: Evidences were achieved by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct. RESULTS: Extensive studies have indicated that aberrant epigenetic modifications could serve as potential biomarkers for diagnosis, prognosis and prediction of colorectal cancer. CONCLUSION: Advances in aberrant epigenetic modifications can open new avenues for exploration of reliable and robust biomarkers to improve the management of CRC patients.
CONTEXT: Colorectal cancer is one of the most common cancers worldwide. Epigenetic alterations play an important role in the pathogenesis of the colorectal cancer. OBJECTIVE: This review has focused on the most recent investigations, which has suggested potential epigenetic biomarkers in colorectal cancer. METHODS: Evidences were achieved by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct. RESULTS: Extensive studies have indicated that aberrant epigenetic modifications could serve as potential biomarkers for diagnosis, prognosis and prediction of colorectal cancer. CONCLUSION: Advances in aberrant epigenetic modifications can open new avenues for exploration of reliable and robust biomarkers to improve the management of CRCpatients.
Entities:
Keywords:
Colorectal cancer; DNA methylation; biomarker; epigenetics; histone modifications; miRNA