BACKGROUND: As part of the perinatal component of the French Human Biomonitoring (HBM) program, biomarkers levels of various chemicals have been described among pregnant women having given birth in continental France in 2011 and who have been enrolled in the Elfe cohort (French Longitudinal Study since Childhood). This paper describes the design of the study and provides main descriptive results regarding exposure biomarkers levels. METHODS: Exposure biomarkers were measured in biological samples collected at delivery from pregnant women randomly selected among the participants in the clinical and biological component of the Elfe cohort (n=4145). The geometric mean and percentiles of the levels distribution were estimated for each biomarker. The sampling design was taken into account in order to obtain estimates representative of the French pregnant women in 2011. RESULTS: Results provide a nation-wide representative description of biomarker levels for important environmental contaminants among pregnant women who gave birth in France in 2011. Bisphenol A (BPA), and some metabolites of phthalates, pesticides (mainly pyrethroids), dioxins, furans, polychlorobiphenyls (PCBs), brominated flame retardants (BFRs), perfluorinated compounds (PFCs) and metals (except uranium) were quantified in almost 100% of the pregnant women. Some compounds showed a downward trend compared to previous studies (lead, mercury), but others did not (pyrethroids) and should be further monitored. CONCLUSION AND PERSPECTIVES: The present results show that French pregnant women are exposed to a wide variety of pollutants, including some that have been banned or restricted in France.
BACKGROUND: As part of the perinatal component of the French Human Biomonitoring (HBM) program, biomarkers levels of various chemicals have been described among pregnant women having given birth in continental France in 2011 and who have been enrolled in the Elfe cohort (French Longitudinal Study since Childhood). This paper describes the design of the study and provides main descriptive results regarding exposure biomarkers levels. METHODS: Exposure biomarkers were measured in biological samples collected at delivery from pregnant women randomly selected among the participants in the clinical and biological component of the Elfe cohort (n=4145). The geometric mean and percentiles of the levels distribution were estimated for each biomarker. The sampling design was taken into account in order to obtain estimates representative of the French pregnant women in 2011. RESULTS: Results provide a nation-wide representative description of biomarker levels for important environmental contaminants among pregnant women who gave birth in France in 2011. Bisphenol A (BPA), and some metabolites of phthalates, pesticides (mainly pyrethroids), dioxins, furans, polychlorobiphenyls (PCBs), brominated flame retardants (BFRs), perfluorinated compounds (PFCs) and metals (except uranium) were quantified in almost 100% of the pregnant women. Some compounds showed a downward trend compared to previous studies (lead, mercury), but others did not (pyrethroids) and should be further monitored. CONCLUSION AND PERSPECTIVES: The present results show that French pregnant women are exposed to a wide variety of pollutants, including some that have been banned or restricted in France.
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Authors: Christina Vaughan Watson; Michael Lewin; Angela Ragin-Wilson; Robert Jones; Jeffery M Jarrett; Kristen Wallon; Cynthia Ward; Nolan Hilliard; Elizabeth Irvin-Barnwell Journal: Environ Res Date: 2020-01-31 Impact factor: 6.498
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Authors: Allison Kupsco; Haotian Wu; Antonia M Calafat; Marianthi-Anna Kioumourtzoglou; Marcela Tamayo-Ortiz; Ivan Pantic; Alejandra Cantoral; Maricruz Tolentino; Emily Oken; Joseph M Braun; Andrea L Deierlein; Robert O Wright; Martha M Téllez-Rojo; Andrea A Baccarelli; Allan C Just Journal: Environ Res Date: 2020-10-14 Impact factor: 6.498
Authors: Niladri Basu; Milena Horvat; David C Evers; Irina Zastenskaya; Pál Weihe; Joanna Tempowski Journal: Environ Health Perspect Date: 2018-10 Impact factor: 9.031
Authors: Amber L Cathey; Deborah Watkins; Zaira Y Rosario; Carmen Vélez; Akram N Alshawabkeh; José F Cordero; John D Meeker Journal: J Endocr Soc Date: 2019-04-11
Authors: Katarina Baralić; Aleksandra Buha Djordjevic; Katarina Živančević; Evica Antonijević; Milena Anđelković; Dragana Javorac; Marijana Ćurčić; Zorica Bulat; Biljana Antonijević; Danijela Đukić-Ćosić Journal: Int J Environ Res Public Health Date: 2020-01-23 Impact factor: 3.390