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Literature DB >> 27787846

Characterizing F-actin Disassembly Induced by the Semaphorin-Signaling Component MICAL.

Jimok Yoon¹, Ruei-Jiun Hung^1,2, Jonathan R Terman³.

Abstract

The MICALs are a family of phylogenetically conserved cytoplasmic proteins that modulate numerous cellular behaviors and play critical roles in semaphorin-plexin signaling. Our recent results have revealed that the MICALs are an unusual family of actin regulatory proteins that use actin filaments (F-actin) as a direct substrate-controlling F-actin dynamics via stereospecific oxidation of conserved methionine (Met44 and Met47) residues within actin. In particular, the MICALs have a highly conserved flavoprotein monooxygenase (redox) enzymatic domain in their N-terminus that directly oxidizes and destabilizes F-actin. Here, we describe methods to characterize MICAL-mediated F-actin disassembly using in vitro assays with purified proteins.

Entities: Chemical Disease Gene Mutation Species

Keywords: Actin sedimentation; F-actin disassembly; MICALs; Oxidoreductase; Plexin; Pyrene-actin

Mesh：

Substances：

Year: 2017 PMID： 27787846 PMCID： PMC5563128 DOI： 10.1007/978-1-4939-6448-2_8

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

30 in total

1. Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.

Authors: Jing Luo; Yali Xu; Qiong Zhu; Fenghua Zhao; Ying Zhang; Xi Peng; Wei Wang; Xuefeng Wang
Journal: Synapse Date: 2011-06-17 Impact factor: 2.562

Review 2. Mechanisms and molecules of neuronal wiring: a primer.

Authors: Alex L Kolodkin; Marc Tessier-Lavigne
Journal: Cold Spring Harb Perspect Biol Date: 2011-06-01 Impact factor: 10.005

3. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.

Authors: Yeping Zhou; Youri Adolfs; W W M Pim Pijnappel; Stephen J Fuller; Roel C Van der Schors; Ka Wan Li; Peter H Sugden; August B Smit; Alexander Hergovich; R Jeroen Pasterkamp
Journal: Mol Cell Biol Date: 2011-07-05 Impact factor: 4.272

4. Differential regulation of actin microfilaments by human MICAL proteins.

Authors: Sai Srinivas Panapakkam Giridharan; Jennifer L Rohn; Naava Naslavsky; Steve Caplan
Journal: J Cell Sci Date: 2012-02-13 Impact factor: 5.285

5. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.

Authors: Shingo Ashida; Mutsuo Furihata; Toyomasa Katagiri; Kenji Tamura; Yoshio Anazawa; Hiroki Yoshioka; Tsuneharu Miki; Tomoaki Fujioka; Taro Shuin; Yusuke Nakamura; Hidewaki Nakagawa
Journal: Clin Cancer Res Date: 2006-05-01 Impact factor: 12.531

6. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.

Authors: R Jeroen Pasterkamp; Hai-ning Dai; Jonathan R Terman; Karl J Wahlin; Byung Kim; Barbara S Bregman; Phillip G Popovich; Alex L Kolodkin
Journal: Mol Cell Neurosci Date: 2005-10-17 Impact factor: 4.314

7. A multidimensional analysis of genes mutated in breast and colorectal cancers.

Authors: Jimmy Lin; Christine M Gan; Xiaosong Zhang; Siân Jones; Tobias Sjöblom; Laura D Wood; D Williams Parsons; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Giovanni Parmigiani; Victor E Velculescu
Journal: Genome Res Date: 2007-08-10 Impact factor: 9.043

Characterizing F-actin Disassembly Induced by the Semaphorin-Signaling Component MICAL.

1. Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.

Review 2. Mechanisms and molecules of neuronal wiring: a primer.

3. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.

4. Differential regulation of actin microfilaments by human MICAL proteins.

5. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.

6. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.

7. A multidimensional analysis of genes mutated in breast and colorectal cancers.

8. A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning.

Review 9. MICALs in control of the cytoskeleton, exocytosis, and cell death.

Review 10. Pyrene: a probe to study protein conformation and conformational changes.

Review 1. Regulated methionine oxidation by monooxygenases.

2. The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.