Dean Eliott1, Tomasz P Stryjewski, Michael T Andreoli, Christopher M Andreoli. 1. *Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; †Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; ‡Department of Ophthalmology, The University of Illinois at Chicago, Chicago, Illinois; and §Harvard Vanguard Medical Associates, Boston, Massachusetts.
Abstract
PURPOSE: To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy after open-globe trauma in smokers and nonsmokers. METHODS: A total of 892 patients comprising 893 open-globe injuries, in whom 255 eyes were diagnosed with a retinal detachment, and 138 underwent surgical repair were analyzed in a retrospective case-control study. Time to redetachment was examined using the Kaplan-Meier method and analysis of risk factors was analyzed using Cox proportional hazards modeling. RESULTS: Within one year after retinal detachment surgery, 47% (95% CI, 39-56%) of all 138 repaired retinas redetached because of proliferative vitreoretinopathy. Being a smoker was associated with a higher rate of detachment (adjusted hazard ratio 1.96, P = 0.01). As shown in previous studies, the presence of proliferative vitreoretinopathy at the time of surgery was also an independent risk factor for failure (adjusted hazard ratio 2.13, P = 0.005). Treatment with vitrectomy-buckle compared favorably to vitrectomy alone (adjusted hazard ratio 0.58, P = 0.04). Only 8% of eyes that redetached achieved a best-corrected visual acuity of 20/200 or better, in comparison to 44% of eyes that did not redetach (P < 0.001). CONCLUSION: Proliferative vitreoretinopathy is a common complication after the repair of retinal detachment associated with open-globe trauma, and being a smoker is a risk factor for redetachment. Further study is needed to understand the pathophysiologic mechanisms underlying this correlation.
PURPOSE: To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy after open-globe trauma in smokers and nonsmokers. METHODS: A total of 892 patients comprising 893 open-globe injuries, in whom 255 eyes were diagnosed with a retinal detachment, and 138 underwent surgical repair were analyzed in a retrospective case-control study. Time to redetachment was examined using the Kaplan-Meier method and analysis of risk factors was analyzed using Cox proportional hazards modeling. RESULTS: Within one year after retinal detachment surgery, 47% (95% CI, 39-56%) of all 138 repaired retinas redetached because of proliferative vitreoretinopathy. Being a smoker was associated with a higher rate of detachment (adjusted hazard ratio 1.96, P = 0.01). As shown in previous studies, the presence of proliferative vitreoretinopathy at the time of surgery was also an independent risk factor for failure (adjusted hazard ratio 2.13, P = 0.005). Treatment with vitrectomy-buckle compared favorably to vitrectomy alone (adjusted hazard ratio 0.58, P = 0.04). Only 8% of eyes that redetached achieved a best-corrected visual acuity of 20/200 or better, in comparison to 44% of eyes that did not redetach (P < 0.001). CONCLUSION:Proliferative vitreoretinopathy is a common complication after the repair of retinal detachment associated with open-globe trauma, and being a smoker is a risk factor for redetachment. Further study is needed to understand the pathophysiologic mechanisms underlying this correlation.
Authors: Dhanesh Amarnani; Arturo Israel Machuca-Parra; Lindsay L Wong; Christina K Marko; James A Stefater; Tomasz P Stryjewski; Dean Eliott; Joseph F Arboleda-Velasquez; Leo A Kim Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799
Authors: Santiago Delgado-Tirado; Dhanesh Amarnani; Guannan Zhao; Elizabeth J Rossin; Dean Eliott; John B Miller; Whitney A Greene; Leslie Ramos; Said Arevalo-Alquichire; David Leyton-Cifuentes; Lucia Gonzalez-Buendia; Daniela Isaacs-Bernal; Hannah A B Whitmore; Natalia Chmielewska; Brandon V Duffy; Eric Kim; Heuy-Ching Wang; Jose M Ruiz-Moreno; Leo A Kim; Joseph F Arboleda-Velasquez Journal: Sci Rep Date: 2020-11-30 Impact factor: 4.379
Authors: Victor Wang; Alison Heffer; Elisa Roztocil; Steven E Feldon; Richard T Libby; Collynn F Woeller; Ajay E Kuriyan Journal: PLoS One Date: 2022-09-01 Impact factor: 3.752
Authors: Nicolas A Yannuzzi; Charles Li; Danielle Fujino; Scott P Kelly; Flora Lum; Harry W Flynn; D Wilkin Parke Journal: JAMA Ophthalmol Date: 2021-06-17 Impact factor: 8.253