| Literature DB >> 27785902 |
Sarah Sauchelli1,2, Susana Jiménez-Murcia1,2,3, Jose C Fernández-García2,4, Lourdes Garrido-Sánchez2,4, Francisco J Tinahones2,4, Felipe F Casanueva2,5, Rosa M Baños2,6, Cristina Botella2,7, Ana B Crujeiras2,5, Rafael de la Torre2,8,9, Jose M Fernández-Real2,10, Gema Frühbeck2,11, Roser Granero2,12, Francisco J Ortega2,10, Amaia Rodríguez2,11, Stephan Zipfel13, Katrin E Giel13, Jose M Menchón1,3,14, Fernando Fernández-Aranda15,16,17.
Abstract
The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index.Entities:
Keywords: body mass index; obesity; orexin; sleep
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Year: 2016 PMID： 27785902 DOI： 10.1002/erv.2484
Source DB: PubMed Journal: Eur Eat Disord Rev ISSN： 1072-4133