Literature DB >> 27785545

Leprosy with ulnar nerve abscess: ultrasound findings in a child.

Helena Barbosa Lugão1, Marco Andrey Cipriani Frade2, Nilton Mazzer3, Norma Tiraboschi Foss2, Marcello Henrique Nogueira-Barbosa4.   

Abstract

We report the ultrasound findings of a typical case of nerve abscess due to leprosy in an 11-year-old boy. The patient had previously undergone pediatric multibacillary leprosy multidrug therapy (MDT) in accordance with World Health Organization guidelines. He presented to our service with bilateral ulnar neuritis with no response to prednisone (1 mg/kg). Right ulnar nerve ultrasound revealed nerve hypoechogenicity, fascicular pattern disorganization, marked fusiform thickening, and a round anechoic area suggestive of intraneural abscess. Intense intraneural power Doppler signal was detected, indicating active neuritis. Intravenous methylprednisolone had a poor response and the patient was submitted to ulnar nerve decompression, which confirmed nerve abscess with purulent discharge during surgery. As the patient weighed more than 40 kg, treatment with a pediatric dose was considered insufficient and adult-dose MDT was prescribed, with improvement of nerve pain and function. Although leprosy is rare in developed countries, it still exists in the USA and it is endemic in many developing countries. Leprosy neuropathy is responsible for the most serious complications of the disease, which can lead to irreversible impairments and deformities. Nerve abscess is an uncommon complication of leprosy and ultrasound can efficiently demonstrate this condition, allowing for prompt treatment. There is scant literature about the imaging findings of nerve abscess in leprosy patients. Radiologists should suspect leprosy in patients with no other known causes of neuropathy when detecting asymmetric nerve enlargement and nerve abscess on ultrasound.

Entities:  

Keywords:  Leprosy; Nerve abscess; Neuropathy; Ultrasound

Mesh:

Year:  2016        PMID: 27785545     DOI: 10.1007/s00256-016-2517-1

Source DB:  PubMed          Journal:  Skeletal Radiol        ISSN: 0364-2348            Impact factor:   2.199


  23 in total

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Journal:  AJR Am J Roentgenol       Date:  1999-09       Impact factor: 3.959

Review 2.  The role of radiology in nerve function impairment and its musculoskeletal complications in leprosy.

Authors:  Frederik J Slim; William R Faber; Mario Maas
Journal:  Lepr Rev       Date:  2009-12       Impact factor: 0.537

3.  Nerve damage in leprosy: a continuing challenge to scientists, clinicians and service providers.

Authors:  Diana N Lockwood; Paul R Saunderson
Journal:  Int Health       Date:  2012-06       Impact factor: 2.473

4.  Leprosy as a neurological disease.

Authors: 
Journal:  Lancet Neurol       Date:  2009-03       Impact factor: 44.182

5.  Solitary neurofibroma mimicking nerve abscess.

Authors:  K Ramanujam
Journal:  Indian J Lepr       Date:  1993 Jul-Sep

6.  Primary neuritic leprosy: a reappraisal at a tertiary care hospital.

Authors:  V Mendiratta; A Khan; A Jain
Journal:  Indian J Lepr       Date:  2006 Jul-Sep

7.  Mycobacterium haemophilum infection with prominent facial manifestation mimicking leprosy.

Authors:  Kentaro Ishii; Norihisa Ishii; Kazue Nakanaga; Kazuaki Nakano; Ikuo Saito; Akihiko Asahina
Journal:  J Dermatol       Date:  2015-05-28       Impact factor: 4.005

Review 8.  Leprosy and the peripheral nervous system: basic and clinical aspects.

Authors:  Winnie W Ooi; Jayashri Srinivasan
Journal:  Muscle Nerve       Date:  2004-10       Impact factor: 3.217

9.  Incidence of Hansen's Disease--United States, 1994-2011.

Authors:  Leisha Nolen; Dana Haberling; David Scollard; Richard Truman; Alfonso Rodriguez-Lainz; Laura Blum; David Blaney
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2014-10-31       Impact factor: 17.586

10.  Asymmetric Nerve Enlargement: A Characteristic of Leprosy Neuropathy Demonstrated by Ultrasonography.

Authors:  Helena Barbosa Lugão; Marcello Henrique Nogueira-Barbosa; Wilson Marques; Norma Tiraboschi Foss; Marco Andrey Cipriani Frade
Journal:  PLoS Negl Trop Dis       Date:  2015-12-08
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  4 in total

1.  Characteristics of Grade 2 Disability in Indonesian Children with Leprosy: A Five-Year Multicenter Retrospective Study.

Authors:  Hendra Gunawan; Atika Kamilia; Sri Linuwih Menaldi; Melani Marissa; Cita Rosita Sigit Prakoeswa; Medhi Denisa Alinda; Dhelya Widasmara; Santosa Basuki; Qaira Anum; Tutty Ariani; Enricco H Mamuaja; Luh Made Mas Rusyati
Journal:  Clin Cosmet Investig Dermatol       Date:  2021-09-01

2.  Point-of-care ultrasound of peripheral nerves in the diagnosis of Hansen's disease neuropathy.

Authors:  Glauber Voltan; Fred Bernards Filho; Marcel Nani Leite; Natália Aparecida De Paula; Jaci Maria Santana; Claudia Maria Lincoln Silva; Josafá Gonçalves Barreto; Moises Batista Da Silva; Guilherme Conde; Claudio Guedes Salgado; Marco Andrey Cipriani Frade
Journal:  Front Med (Lausanne)       Date:  2022-09-09

Review 3.  Neuromuscular ultrasound in clinical practice: A review.

Authors:  Natalia L Gonzalez; Lisa D Hobson-Webb
Journal:  Clin Neurophysiol Pract       Date:  2019-07-12

4.  Endoneural abscess of common popliteal nerve as first clinical manifestation of leprosy: the first reported case in history in a low-incidence country.

Authors:  A Balestrino; N Riccardi; P Fiaschi; P Anania; C Martinoli; S Gennaro
Journal:  J Prev Med Hyg       Date:  2020-07-04
  4 in total

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