| Literature DB >> 27784212 |
Ekaterina I Finkina1, Daria N Melnikova1, Ivan V Bogdanov1, Tatiana V Ovchinnikova1.
Abstract
Pathogenesis-related (PR) proteins are components of innate immunity system in plants. They play an important role in plant defense against pathogens. Lipid transfer proteins (LTPs) and Bet v 1 homologs comprise of two separate families of PR-proteins. Both LTPs (PR-14) and Bet v 1 homologs (PR-10) are multifunctional small proteins involving in plant response to abiotic and biotic stress conditions. The representatives of these PR-protein families do not show any sequence similarity but have other common biochemical features such as low molecular masses, the presence of hydrophobic cavities, ligand binding properties, and antimicrobial activities. Besides, many members of PR-10 and PR-14 families are ubiquitous plant panallergens which are able to cause sensitization of human immune system and crossreactive allergic reactions to plant food and pollen. This review is aimed at comparative analysis of structure-functional and allergenic properties of the PR-10 and PR-14 families, as well as prospects for their medicinal application. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Bet v 1 homologs; Innate immunity system; allergens; cross reactivity; ligand binding; lipid transferzzm321990proteins; pathogenesis-related proteins; plant defense
Mesh：
Substances：
Year: 2017 PMID： 27784212 DOI： 10.2174/0929867323666161026154111
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530