Jianjun Ou1, Ming Li2, Xiao Xiao2. 1. a Mental Health Institute of the Second Xiangya Hospital, Central South University , Changsha , Hunan , China. 2. b Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China.
Abstract
OBJECTIVES: Genome-wide association studies (GWAS) followed by independent replications suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial genetic overlap between SCZ and major mood disorders (e.g., bipolar disorder (BPD) and major depressive disorder (MDD)). METHODS: We collected the data of two ZNF804A single-nucleotide polymorphisms (SNPs rs1344706 and rs7597593) from European and Asian populations to perform systematic meta-analyses with major mood disorders in a total of 65,240 subjects. RESULTS: Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance. CONCLUSIONS: Our data provide evidence for the genetic involvement of ZNF804A SNPs in the susceptibility of major mood disorders, but further replication analyses in larger samples are necessary.
OBJECTIVES: Genome-wide association studies (GWAS) followed by independent replications suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial genetic overlap between SCZ and major mood disorders (e.g., bipolar disorder (BPD) and major depressive disorder (MDD)). METHODS: We collected the data of two ZNF804A single-nucleotide polymorphisms (SNPs rs1344706 and rs7597593) from European and Asian populations to perform systematic meta-analyses with major mood disorders in a total of 65,240 subjects. RESULTS: Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance. CONCLUSIONS: Our data provide evidence for the genetic involvement of ZNF804A SNPs in the susceptibility of major mood disorders, but further replication analyses in larger samples are necessary.
Entities:
Keywords:
GWAS; ZNF804A; bipolar disorder; major depressive disorder; schizophrenia
Authors: Xiao Xiao; Lu Wang; Chuang Wang; Ti-Fei Yuan; Dongsheng Zhou; Fanfan Zheng; Lingyi Li; Maria Grigoroiu-Serbanescu; Masashi Ikeda; Nakao Iwata; Atsushi Takahashi; Yoichiro Kamatani; Michiaki Kubo; Martin Preisig; Zoltán Kutalik; Enrique Castelao; Giorgio Pistis; Najaf Amin; Cornelia M van Duijn; Andreas J Forstner; Jana Strohmaier; Julian Hecker; Thomas G Schulze; Bertram Müller-Myhsok; Andreas Reif; Philip B Mitchell; Nicholas G Martin; Peter R Schofield; Sven Cichon; Markus M Nöthen; Hong Chang; Xiong-Jian Luo; Yiru Fang; Yong-Gang Yao; Chen Zhang; Marcella Rietschel; Ming Li Journal: Transl Psychiatry Date: 2017-12-11 Impact factor: 6.222