| Literature DB >> 27783333 |
Craig A Marshall1, Ivan A Borbon1,2, Robert P Erickson3.
Abstract
Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 nih / Npc1 nih mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.Entities:
Keywords: Histone deacetylase; Nicotinamide; Niemann-Pick C1 disease; Oxidative stress; Sirtuin; Valproic acid
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Year: 2016 PMID： 27783333 DOI： 10.1007/s13353-016-0367-0
Source DB: PubMed Journal: J Appl Genet ISSN： 1234-1983 Impact factor: 3.240