Literature DB >> 2778316

Two better cell lines for making hybridomas expressing specific T cell receptors.

J White1, M Blackman, J Bill, J Kappler, P Marrack, D P Gold, W Born.   

Abstract

Two variants of the AKR thymoma BW5147 have been isolated which can no longer express functional TCR alpha- and beta-chains. By generating hybridomas with these variant fusion lines, TCR of any normal T lymphocyte, including TCR-gamma/delta, can be studied at a clonal level, without interference of the BW5147-derived receptor chains. In this study one of the variants has been useful in identifying the reactivity to allogeneic MHC Ag of BW5147 itself.

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Year:  1989        PMID： 2778316

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  99 in total

1.  An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro.

Authors:  W Rees; J Bender; T K Teague; R M Kedl; F Crawford; P Marrack; J Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Natural killer 1.1(+) alpha beta T cells in the periimplantation uterus.

Authors:  Y Dang; J Beckers; C R Wang; K D Heyborne
Journal:  Immunology       Date:  2000-12       Impact factor: 7.397

3.  Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing.

Authors:  S Surman; T D Lockey; K S Slobod; B Jones; J M Riberdy; S W White; P C Doherty; J L Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-03       Impact factor: 11.205

4.  Susceptibility to cell death is a dominant phenotype: triggering of activation-driven T-cell death independent of the T-cell antigen receptor complex.

Authors:  G Nickas; J Meyers; L D Hebshi; J D Ashwell; D P Gold; B Sydora; D S Ucker
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

5.  Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.

Authors:  Yoshiyuki Goto; Casandra Panea; Gaku Nakato; Anna Cebula; Carolyn Lee; Marta Galan Diez; Terri M Laufer; Leszek Ignatowicz; Ivaylo I Ivanov
Journal:  Immunity       Date:  2014-03-27       Impact factor: 31.745

6.  Inducible functions in hybrids of a Lyt-2+ BW5147 transfectant and the 2C CTL line.

Authors:  J J Gu; P D Gottlieb
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

7.  Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice.

Authors:  R L Yauch; K Kerekes; K Saujani; B S Kim
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

8.  Conserved T-cell receptor class II major histocompatibility complex contact detected in a T-lymphocyte population.

Authors:  M Feng; D Chou; Y Liaw; M Lai
Journal:  Immunology       Date:  1998-10       Impact factor: 7.397

9.  Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity.

Authors:  Rajshekhar Alli; Phuong Nguyen; Terrence L Geiger
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422

10.  Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23.

Authors:  Li Zhang; Niyun Jin; Maki Nakayama; Rebecca L O'Brien; George S Eisenbarth; Willi K Born
Journal:  J Autoimmun       Date:  2010-01-18       Impact factor: 7.094
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