Literature DB >> 27783158

Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology.

Samriti Dogra1, Frederick Kaskel2.   

Abstract

Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

Entities:  

Keywords:  Focal segmental glomerulosclerosis; Genetic testing; Glomerular filtration barrier; Minimal change disease; Podocyte; Steroid-resistant nephrotic syndrome

Mesh：

Substances：

Year:  2016        PMID： 27783158     DOI： 10.1007/s00467-016-3459-5

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  51 in total

1.  Recurrence of idiopathic nephrotic syndrome after renal transplantation. 1972.

Authors: 
Journal:  J Am Soc Nephrol       Date:  2001-09       Impact factor: 10.121

2.  Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.

Authors:  J M Kaplan; S H Kim; K N North; H Rennke; L A Correia; H Q Tong; B J Mathis; J C Rodríguez-Pérez; P G Allen; A H Beggs; M R Pollak
Journal:  Nat Genet       Date:  2000-03       Impact factor: 38.330

3.  The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis.

Authors:  Björn Meijers; Rutger J H Maas; Ben Sprangers; Kathleen Claes; Ruben Poesen; Bert Bammens; Maarten Naesens; Jeroen K J Deegens; Ruth Dietrich; Markus Storr; Jack F M Wetzels; Pieter Evenepoel; Dirk Kuypers
Journal:  Kidney Int       Date:  2014-01-08       Impact factor: 10.612

4.  NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.

Authors:  N Boute; O Gribouval; S Roselli; F Benessy; H Lee; A Fuchshuber; K Dahan; M C Gubler; P Niaudet; C Antignac
Journal:  Nat Genet       Date:  2000-04       Impact factor: 38.330

5.  Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection.

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Journal:  Blood       Date:  2000-12-15       Impact factor: 22.113

Review 6.  Genetic testing in nephrotic syndrome--challenges and opportunities.

Authors:  Rasheed A Gbadegesin; Michelle P Winn; William E Smoyer
Journal:  Nat Rev Nephrol       Date:  2013-01-15       Impact factor: 28.314

7.  ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.

Authors:  Heon Yung Gee; Pawaree Saisawat; Shazia Ashraf; Toby W Hurd; Virginia Vega-Warner; Humphrey Fang; Bodo B Beck; Olivier Gribouval; Weibin Zhou; Katrina A Diaz; Sivakumar Natarajan; Roger C Wiggins; Svjetlana Lovric; Gil Chernin; Dominik S Schoeb; Bugsu Ovunc; Yaacov Frishberg; Neveen A Soliman; Hanan M Fathy; Heike Goebel; Julia Hoefele; Lutz T Weber; Jeffrey W Innis; Christian Faul; Zhe Han; Joseph Washburn; Corinne Antignac; Shawn Levy; Edgar A Otto; Friedhelm Hildebrandt
Journal:  J Clin Invest       Date:  2013-07-08       Impact factor: 14.808

Review 8.  Involvement of tumor necrosis factor-alpha in the pathogenesis of experimental and human glomerulonephritis.

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Journal:  Adv Nephrol Necker Hosp       Date:  1995

9.  FSGS permeability factor-associated nephrotic syndrome: remission after oral galactose therapy.

Authors:  Eric De Smet; Jean-Philippe Rioux; Hélène Ammann; Clément Déziel; Serge Quérin
Journal:  Nephrol Dial Transplant       Date:  2009-06-09       Impact factor: 5.992

10.  Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities.

Authors:  Martin Zenker; Thomas Aigner; Olaf Wendler; Tim Tralau; Horst Müntefering; Regina Fenski; Susanne Pitz; Valérie Schumacher; Brigitte Royer-Pokora; Elke Wühl; Pierre Cochat; Raymonde Bouvier; Cornelia Kraus; Karlheinz Mark; Henry Madlon; Jörg Dötsch; Wolfgang Rascher; Iwona Maruniak-Chudek; Thomas Lennert; Luitgard M Neumann; André Reis
Journal:  Hum Mol Genet       Date:  2004-09-14       Impact factor: 6.150
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  9 in total

Review 1.  The status quo and challenges of genetic diagnosis in children with steroid-resistant nephrotic syndrome.

Authors:  Yan-Yan Jin; Bing-Yu Feng; Jian-Hua Mao
Journal:  World J Pediatr       Date:  2018-04-11       Impact factor: 2.764

2.  COQ2 nephropathy: a treatable cause of nephrotic syndrome in children.

Authors:  Michelle C Starr; Irene J Chang; Laura S Finn; Angela Sun; Austin A Larson; Jens Goebel; Coral Hanevold; Jenny Thies; Johan L K Van Hove; Sangeeta R Hingorani; Christina Lam
Journal:  Pediatr Nephrol       Date:  2018-04-10       Impact factor: 3.714

Review 3.  Xenopus: Driving the Discovery of Novel Genes in Patient Disease and Their Underlying Pathological Mechanisms Relevant for Organogenesis.

Authors:  Woong Y Hwang; Jonathan Marquez; Mustafa K Khokha
Journal:  Front Physiol       Date:  2019-07-30       Impact factor: 4.566

4.  Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach.

Authors:  Xiaoqin Ma; Meixiang Yu; Chenxia Hao; Wanhua Yang
Journal:  Evid Based Complement Alternat Med       Date:  2020-01-06       Impact factor: 2.629

5.  Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis.

Authors:  Hong-Yan Li; Xialan Zhang; Tianbiao Zhou; Zhiqing Zhong; Hongzhen Zhong
Journal:  BMC Nephrol       Date:  2019-10-23       Impact factor: 2.388

6.  Study of the Therapeutic Effects of Chinese Herbal Decoction Combined with Glucocorticoid in Treating Primary Nephrotic Syndrome in Children.

Authors:  Xue Hou; Meihua Xu; Jie Li; Rui Li; Jinzhi Zhang; Jing Ju
Journal:  Evid Based Complement Alternat Med       Date:  2021-11-19       Impact factor: 2.629

7.  The effectiveness of cyclosporine A for patients with steroid-resistant nephrotic syndrome: A protocol for systematic review and meta-analysis.

Authors:  Juan Lv; Shizhi Luo; Yunxia Zhang; Enlai Dai
Journal:  Medicine (Baltimore)       Date:  2021-12-10       Impact factor: 1.817

Review 8.  Advances in pediatrics in 2017: current practices and challenges in allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology from the perspective of Italian Journal of Pediatrics.

Authors:  Carlo Caffarelli; Francesca Santamaria; Dora Di Mauro; Carla Mastrorilli; Silvia Montella; Bertrand Tchana; Giuliana Valerio; Alberto Verrotti; Mariella Valenzise; Sergio Bernasconi; Giovanni Corsello
Journal:  Ital J Pediatr       Date:  2018-07-17       Impact factor: 2.638

Review 9.  Current understandings in treating children with steroid-resistant nephrotic syndrome.

Authors:  Jae Il Shin; Jun Oh; Jiwon M Lee; Andreas Kronbichler
Journal:  Pediatr Nephrol       Date:  2020-02-21       Impact factor: 3.714
  9 in total

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