Vincent Planche1, Aurélie Ruet2, Pierrick Coupé3, Delphine Lamargue-Hamel4, Mathilde Deloire5, Bruno Pereira6, José V Manjon7, Fanny Munsch4, Nicola Moscufo8, Dominik S Meier8, Charles Rg Guttmann9, Vincent Dousset2, Bruno Brochet2, Thomas Tourdias2. 1. Universite de Bordeaux, Bordeaux, France/Inserm U1215, Neurocentre Magendie, Bordeaux, France/Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. 2. Universite de Bordeaux, Bordeaux, France/Inserm U1215, Neurocentre Magendie, Bordeaux, France/Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France. 3. Laboratoire Bordelais de Recherche en Informatique (LaBRI), Talence, France. 4. Universite de Bordeaux, Bordeaux, France/Inserm U1215, Neurocentre Magendie, Bordeaux, France. 5. Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France. 6. Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. 7. Universitat Politècnica de València, Valencia, Spain. 8. Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 9. Universite de Bordeaux, Bordeaux, France/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
OBJECTIVE: We investigated whether diffusion tensor imaging (DTI) could reveal early hippocampal damage and clinically relevant correlates of memory impairment in persons with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). METHODS: A total of 37 persons with CIS, 32 with MS and 36 controls prospectively included from 2011 to 2014 were tested for cognitive performances and scanned with 3T-magnetic resonance imaging (MRI) to assess volumetric and DTI changes within the hippocampus, whole brain volume and T2-lesion load. RESULTS: While there was no hippocampal atrophy in the CIS group, hippocampal fractional anisotropy (FA) was significantly decreased compared to controls. Decrease in hippocampal FA together with increased mean diffusivity (MD) was even more prominent in MS patients. In CIS, hippocampal MD was correlated with episodic verbal memory performance ( r = -0.57, p = 0.0002 and odds ratio (OR) = 0.058, 95% confidence interval (CI) = 0.0057-0.59, p = 0.016 adjusted for age, gender, depression and T2-lesion load), but not with cognitive tasks unrelated to hippocampal functions. Hippocampal MD was the only variable discriminating memory-impaired from memory-preserved persons with CIS (area under the curve (AUC) = 0.77, sensitivity = 90.0%, specificity = 70.3%, positive predictive value (PPV) = 52.9%, negative predictive value (NPV) = 95.0%). CONCLUSION: DTI alterations within the hippocampus might reflect early neurodegenerative processes that are correlated with episodic memory performance, discriminating persons with CIS according to their memory status.
OBJECTIVE: We investigated whether diffusion tensor imaging (DTI) could reveal early hippocampal damage and clinically relevant correlates of memory impairment in persons with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). METHODS: A total of 37 persons with CIS, 32 with MS and 36 controls prospectively included from 2011 to 2014 were tested for cognitive performances and scanned with 3T-magnetic resonance imaging (MRI) to assess volumetric and DTI changes within the hippocampus, whole brain volume and T2-lesion load. RESULTS: While there was no hippocampal atrophy in the CIS group, hippocampal fractional anisotropy (FA) was significantly decreased compared to controls. Decrease in hippocampal FA together with increased mean diffusivity (MD) was even more prominent in MSpatients. In CIS, hippocampal MD was correlated with episodic verbal memory performance ( r = -0.57, p = 0.0002 and odds ratio (OR) = 0.058, 95% confidence interval (CI) = 0.0057-0.59, p = 0.016 adjusted for age, gender, depression and T2-lesion load), but not with cognitive tasks unrelated to hippocampal functions. Hippocampal MD was the only variable discriminating memory-impaired from memory-preserved persons with CIS (area under the curve (AUC) = 0.77, sensitivity = 90.0%, specificity = 70.3%, positive predictive value (PPV) = 52.9%, negative predictive value (NPV) = 95.0%). CONCLUSION: DTI alterations within the hippocampus might reflect early neurodegenerative processes that are correlated with episodic memory performance, discriminating persons with CIS according to their memory status.
Authors: Fei Gao; Xuntao Yin; Richard A E Edden; Alan C Evans; Junhai Xu; Guanmei Cao; Honghao Li; Muwei Li; Bin Zhao; Jian Wang; Guangbin Wang Journal: Hippocampus Date: 2018-11 Impact factor: 3.899
Authors: Hsueh-Sheng Chiang; Alka Khera; Barbara E Stopschinski; Olaf Stuve; John Hart; Brendan Kelley; Trung Nguyen Journal: Geriatrics (Basel) Date: 2022-06-05
Authors: Vincent Planche; Ismail Koubiyr; José E Romero; José V Manjon; Pierrick Coupé; Mathilde Deloire; Vincent Dousset; Bruno Brochet; Aurélie Ruet; Thomas Tourdias Journal: Hum Brain Mapp Date: 2018-01-13 Impact factor: 5.038
Authors: Jessica Podda; Andrea Tacchino; Ludovico Pedullà; Margherita Monti Bragadin; Mario Alberto Battaglia; Giampaolo Brichetto Journal: Mult Scler Date: 2020-10-13 Impact factor: 5.855
Authors: Lisa Glukhovsky; Rachel Brandstadter; Victoria M Leavitt; Stephen Krieger; Korhan Buyukturkoglu; Michelle Fabian; Ilana Katz Sand; Sylvia Klineova; Claire S Riley; Fred D Lublin; Aaron E Miller; James F Sumowski Journal: Mult Scler Date: 2020-06-22 Impact factor: 5.855