Literature DB >> 27777449

3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines.

Rohit Arora1, Rakesh Kumar1, Jyoti Mahajan1, Adarsh P Vig1, Bikram Singh2, Balbir Singh3, Saroj Arora1.   

Abstract

The present study envisages the cytotoxic potential of 3-butenyl isothiocyanate isolated from Brassica juncea L. Czern var. Pusa Jaikisan against the human cancer cell lines viz. prostate, bone osteosarcoma, cervical, liver, neuroblastoma and breast cancer. As the compound was observed to be more effective against prostate cancer cell line, therefore, this cell line was further used to study the mechanism of cell death using neutral red assay, reactive oxygen species assay, mitochondrial membrane potential assay, microscopic and cell cycle analysis. The mechanistic analysis indicated that it induced the cell death of prostate cancer cells via apoptosis and hence made it an excellent choice as an effective anticancer compound.

Entities:  

Keywords:  3-Butenyl isothiocyanate; Anticancer; Caspase-3 activity; Cell line; Glucosinolates

Year:  2016        PMID： 27777449      PMCID： PMC5069244          DOI： 10.1007/s13197-016-2316-7

Source DB:  PubMed          Journal:  J Food Sci Technol        ISSN： 0022-1155            Impact factor:   2.701


  23 in total

1.  Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT.

Authors:  K Abe; N Matsuki
Journal:  Neurosci Res       Date:  2000-12       Impact factor: 3.304

2.  Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.

Authors:  Jo-Hua Chiang; Jai-Sing Yang; Chia-Yu Ma; Mei-Due Yang; Hui-Ying Huang; Te-Chun Hsia; Hsiu-Maan Kuo; Ping-Ping Wu; Tsung-Han Lee; Jing-Gung Chung
Journal:  Chem Res Toxicol       Date:  2010-12-02       Impact factor: 3.739

3.  Study on the autophagy of prostate cancer PC-3 cells induced by oridonin.

Authors:  Li-Hong Ye; Wang-Jian Li; Xiao-Qiang Jiang; Yong-Liang Chen; Shui-Xiang Tao; Wei-Liang Qian; Jian-Song He
Journal:  Anat Rec (Hoboken)       Date:  2011-12-20       Impact factor: 2.064

4.  Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.

Authors:  B González-Flecha; J C Cutrin; A Boveris
Journal:  J Clin Invest       Date:  1993-02       Impact factor: 14.808

5.  Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells.

Authors:  Antonietta Melchini; Maria H Traka; Stefania Catania; Natalizia Miceli; Maria Fernanda Taviano; Patrizia Maimone; Marta Francisco; Richard F Mithen; Chiara Costa
Journal:  Nutr Cancer       Date:  2013       Impact factor: 2.900

6.  Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway.

Authors:  Qingyong Chen; Yanyi Wang; Kedi Xu; Guohua Lu; Zheng Ying; Lijun Wu; Jianwei Zhan; Rui Fang; Yuquan Wu; Jianying Zhou
Journal:  Oncol Rep       Date:  2010-02       Impact factor: 3.906

7.  A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells.

Authors:  Shashi Bhushan; Ajay Kumar; Fayaz Malik; Samar Singh Andotra; Vijay Kumar Sethi; Indu Pal Kaur; Subhash Chandra Taneja; Ghulam Nabi Qazi; Jaswant Singh
Journal:  Apoptosis       Date:  2007-10       Impact factor: 4.677

8.  Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway.

Authors:  Sijun Deng; Hui Yuan; Jine Yi; Yin Lu; Qiang Wei; Chengzhi Guo; Jing Wu; Liyun Yuan; Zuping He
Journal:  J Vet Sci       Date:  2013-06-30       Impact factor: 1.672

9.  Hepatic dysfunction induced by 7, 12-dimethylbenz(α)anthracene and its obviation with erucin using enzymatic and histological changes as indicators.

Authors:  Rohit Arora; Sakshi Bhushan; Rakesh Kumar; Rahul Mannan; Pardeep Kaur; Amrit Pal Singh; Bikram Singh; Adarsh P Vig; Deepika Sharma; Saroj Arora
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

10.  Conventional and modified hydrodistillation method for the extraction of glucosinolate hydrolytic products: a comparative account.

Authors:  Rohit Arora; Bikram Singh; Adarsh Pal Vig; Saroj Arora
Journal:  Springerplus       Date:  2016-04-18
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  4 in total

1.  Correlation of Glucosinolates and Volatile Constituents of Six Brassicaceae Seeds with Their Antioxidant Activities Based on Partial Least Squares Regression.

Authors:  Noha Khalil; Haidy A Gad; Nawal M Al Musayeib; Mokhtar Bishr; Mohamed L Ashour
Journal:  Plants (Basel)       Date:  2022-04-20

2.  Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group) by Methyl Jasmonate.

Authors:  Moo Jung Kim; Yu-Chun Chiu; Na Kyung Kim; Hye Min Park; Choong Hwan Lee; John A Juvik; Kang-Mo Ku
Journal:  Int J Mol Sci       Date:  2017-05-07       Impact factor: 5.923

Review 3.  Dietary Compounds for Targeting Prostate Cancer.

Authors:  Seungjin Noh; Eunseok Choi; Cho-Hyun Hwang; Ji Hoon Jung; Sung-Hoon Kim; Bonglee Kim
Journal:  Nutrients       Date:  2019-10-08       Impact factor: 5.717

4.  Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review.

Authors:  Sylvia Maina; Gerald Misinzo; Gaymary Bakari; Ho-Youn Kim
Journal:  Molecules       Date:  2020-08-12       Impact factor: 4.411
  4 in total

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