BACKGROUND: Delayed diagnosis of Buruli ulcer can worsen clinical presentation of the disease, prolong duration of management, and impose avoidable additional costs on patients and health providers. We investigated the profile, delays in diagnosis, duration of hospitalisation, and associated factors among patients with Buruli ulcer in Nigeria. METHODS: This was a prospective cohort study of patients with Buruli ulcer who were identified from a community-based survey. Data on the patients' clinical profile, delays in diagnosis and duration of hospitalisation were prospectively collected. RESULTS: Of 145 patients notified, 125 (86.2%) were confirmed by one or more laboratory tests (81.4% by PCR). The median age of the patients was 20 years, 88 (60.7%) were >15years old and 85 (58.6%) were females. In addition, 137 (94.5%) were new cases, 119 (82.1%) presented with ulcers and 110 (75.9%) had lower limb lesions. The mean time delay to diagnosis was 50.6 (±101.9) weeks. The mean duration of hospitalisation was 108 (±60) days. Determinants of time delay to diagnosis were higher disease category (p=0.001) and laboratory confirmation of disease (p=0.02). Determinants of longer hospitalisation were; multiple lesions (p=0.035), and having functional limitation at diagnosis and undertaking surgery (p=0.003). CONCLUSIONS: Patients with Buruli ulcer have very long time delays to diagnosis and long hospitalisation during treatment. This calls for early case-finding and improved access to Buruli ulcer services in Nigeria.
BACKGROUND: Delayed diagnosis of Buruli ulcer can worsen clinical presentation of the disease, prolong duration of management, and impose avoidable additional costs on patients and health providers. We investigated the profile, delays in diagnosis, duration of hospitalisation, and associated factors among patients with Buruli ulcer in Nigeria. METHODS: This was a prospective cohort study of patients with Buruli ulcer who were identified from a community-based survey. Data on the patients' clinical profile, delays in diagnosis and duration of hospitalisation were prospectively collected. RESULTS: Of 145 patients notified, 125 (86.2%) were confirmed by one or more laboratory tests (81.4% by PCR). The median age of the patients was 20 years, 88 (60.7%) were >15years old and 85 (58.6%) were females. In addition, 137 (94.5%) were new cases, 119 (82.1%) presented with ulcers and 110 (75.9%) had lower limb lesions. The mean time delay to diagnosis was 50.6 (±101.9) weeks. The mean duration of hospitalisation was 108 (±60) days. Determinants of time delay to diagnosis were higher disease category (p=0.001) and laboratory confirmation of disease (p=0.02). Determinants of longer hospitalisation were; multiple lesions (p=0.035), and having functional limitation at diagnosis and undertaking surgery (p=0.003). CONCLUSIONS:Patients with Buruli ulcer have very long time delays to diagnosis and long hospitalisation during treatment. This calls for early case-finding and improved access to Buruli ulcer services in Nigeria.
Authors: Joseph P Receveur; Alexandra Bauer; Jennifer L Pechal; Sophie Picq; Magdalene Dogbe; Heather R Jordan; Alex W Rakestraw; Kayla Fast; Michael Sandel; Christine Chevillon; Jean-François Guégan; John R Wallace; M Eric Benbow Journal: FEMS Microbiol Rev Date: 2022-01-18 Impact factor: 15.177
Authors: Kingsley N Ukwaja; Chukwuka Alphonsus; Chinwe C Eze; Linda Lehman; Ngozi Ekeke; Charles C Nwafor; Joy Ikebudu; Moses C Anyim; Joseph N Chukwu Journal: PLoS Negl Trop Dis Date: 2020-04-30
Authors: Charles Chukwunalu Nwafor; Anthony Meka; Joseph Ngozi Chukwu; Ngozi Ekeke; Chukwuka Alphonsus; Obinna Mbah; Nelson Okechukwu Madichie; Ufuoma Aduh; Matthew Ogbeifo; Bola Olubakin IseOluwa-Adelokiki; Joseph Ezebunafor Edochie; Joseph Ushaka; Kingsley Nnanna Ukwaja Journal: Afr Health Sci Date: 2019-06 Impact factor: 0.927